Results 141 to 150 of about 146,625,829 (278)
, 2005 In the third of seven clips in Series 3 of Exploring Linear Functions: Graphing and sharing guess my rule problems, researcher Evelyn Hanna asks Ariel, a 7th grade student in an after-school enrichment program, to graph the points for problem 2 on a ...
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Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
, 2005 In the sixth of six clips in Series 4 of Exploring Linear Functions, Ariel, a 7th grade student in an after-school enrichment program, revisits his work on Guess my Rule problem 4 with teacher/intern Gilberto Ladino. After successfully coming up with the
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
, 2005 The last clip of eight in Series One of Exploring Linear Functions occurs during the students' second day exploring Guess My Rule problems. Researcher Iuliana Radu is observing as James prepares the table for his invented problem.
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This article is one of the many attempts to understand the concept of the rule of law in the European Union, Council of Europe and also in the Member States, although only German Rechtsstaat and English Rule of law are taken as examples of the ...
Raitio, Juha
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Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source