Results 1 to 10 of about 762 (96)

Development of esterase-resistant and highly active ghrelin analogs via thiol-ene click chemistry

bioRxiv, 2022
The orexigenic peptide ghrelin exerts important functions in energy metabolism and cellular homeostasis by activating the growth hormone secretagogue receptor type 1a (GHSR1a), and thus has therapeutic potential to treat certain diseases.
Hao-Zheng Li, X. Shao, Li-Li Shou, Ning Li, Ya‐Li Liu, Zeng-guang Xu, Zhan-Yun Guo   +6 more
semanticscholar   +1 more source

Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues

ACS Omega, 2022
Considering the importance of acetylcholine esterase (AChE, BchE) and α-glucosidase in the treatment of Alzheimer’s disease and diabetes mellitus, the synthesis of novel azinane triazole-based derivatives as effective acetylcholinesterase (AchE), α ...
Hafiz Muhammad Abdullah Asif, S. Kamal, A. Rehman, S. Rasool, Muhammad Sajid Hamid Akash   +4 more
semanticscholar   +1 more source

Actividad sérica de la acetilhidrolasa del factor activador de plaquetas en pacientes afrodescendientes y mestizos con dengue, Colombia

Biomédica: revista del Instituto Nacional de Salud, 2011
Introducción. El dengue grave se caracteriza por el aumento de la permeabilidad vascular inducida por citocinas y mediadores químicos; uno de estos es el factor activador de plaquetas.
Berta Nelly Restrepo, Margarita Arboleda, Ruth Ramírez, Gonzalo Álvarez   +3 more
doaj   +1 more source

Prodrugs of γ‐Alkyl‐Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase

Angewandte Chemie, 2020
The development of nucleoside triphosphate prodrugs is one option to apply nucleoside reverse transcriptase inhibitors. Herein, we report the synthesis and evaluation of d4TTP analogues, in which the γ‐phosphate was modified covalently by lipophilic ...
Chenglong Zhao, Stefan Weber, D. Schols, J. Balzarini, C. Meier   +4 more
semanticscholar   +1 more source

Nematicidal action of Clonostachys rosea against Meloidogyne incognita: in-vitro and in-silico analyses

Journal of Taibah University for Science, 2023
Clonostachys rosea is a biocontrol agent against a wide range of pests and diseases. In the present study, an in-vitro nematicidal activity of C. rosea has been documented by observing the behavioural response of Meloidogyne incognita (Mi) towards the ...
Gowrisri Nagaraj, R. Kannan, T. Raguchander, Swarnakumari Narayanan, Duraisamy Saravanakumar   +4 more
semanticscholar   +1 more source

p-Nitrophenyl and cholesteryl-N-alkyl carbamates as inhibitors of cholesterol esterase.

Journal of Biological Chemistry, 1987
p-Nitrophenyl and cholesteryl-N-alkyl carbamates are good inhibitors of porcine pancreatic cholesterol esterase-catalyzed hydrolysis of p-nitrophenyl butyrate.
L. Hosie, L. Sutton, D. Quinn
semanticscholar   +1 more source

Predictive value of lipoprotein - associated phospholipase A2 combined with systemic inflammatory response index in delayed encephalopathy after acute carbon monoxide poisoning

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To examine the levels of systemic inflammatory response index (SIRI) and serum lipoprotein-associated phospholipase A2 (Lp-PLA2) in patients with acute carbon monoxide poisoning (ACOP), and to explore the predictive value of SIRI, Lp - PLA2 and
MI Xiao-lu, QI Hong-na, WANG Wei-zhan, SUN Shao-jie, WU Yan-pin   +4 more
doaj   +1 more source

Purification and Characterization of PrbA, a New Esterase fromEnterobacter cloacae Hydrolyzing the Esters of 4-Hydroxybenzoic Acid (Parabens)*

Journal of Biological Chemistry, 2003
The esterase PrbA from Enterobacter cloacae strain EM has previously been shown to confer additional resistance to the esters of 4-hydroxybenzoic acid (parabens) to two species of Enterobacter. The PrbA protein has been purified from E. cloacae strain EM
N. Valkova, F. Lépine, Louisette Labrie, M. Dupont, R. Beaudet   +4 more
semanticscholar   +1 more source

High-Performance Thin-Layer Chromatography Hyphenated with Microchemical and Biochemical Derivatizations in Bioactivity Profiling of Marine Species

Marine Drugs, 2019
Marine organisms produce an array of biologically active natural products, many of which have unique structures that have not been found in terrestrial organisms. Hence, marine algae provide a unique source of bioactive compounds.
S. Agatonovic-Kustrin, E. Kustrin, V. Gegechkori, D. Morton   +3 more
semanticscholar   +1 more source

The association between circulating Hcy and Lp-PLA2 levels and poststroke depression: A meta-analysis. [PDF]

Medicine (Baltimore), 2023
Tao Y, Wang W, Zhao J, Xu X, Ke J, Ke X.
europepmc   +1 more source