Results 91 to 100 of about 3,850 (205)

Microbial epimerization of 1-deoxynojirimycin to 1-deoxymannojirimycin.

The Journal of Antibiotics, 1989
We attempted to epimerize 1-deoxynojirimycin to produce 1-deoxymannojirimycin, a potent mannosidase inhibitor which blocks conversion of high-mannose to complex saccharide on N-asparagine linked glucan biosynthesis. The data reported describes the microbial conversion of 1-deoxynojirimycin to the manno-form and its glycosidase inhibitory ...
T, Furumoto, N, Asano, Y, Kameda, K, Matsui   +3 more
openaire   +3 more sources

Anwendungen der Olefinmetathese in der Synthese von Azazuckern [PDF]

, 2000
Anwendungen der Olefinmetathese in der Synthese von Azazuckern Polyhydroxylierte Derivate monocyclischer und bicyclischer stickstoffhaltiger Ringsysteme, wie z.B.
Voigtmann, Ulrike
core   +1 more source

Essential Oil From Dittrichia viscosa L.: A Potential Source of Bioactive Substances With Antioxidant, Antimicrobial, and Antidiabetic Properties: In Vitro and In Silico Studies

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2025, Issue 1, 2025.
In Morocco, Dittrichia viscosa L. has long been used to treat a variety of illnesses. The objective of this work was to comprehensively evaluate the essential oil (EO) derived from D. viscosa essential oil (DVEO) for its antibacterial, antidiabetic, and antioxidant effects and to confirm the in vitro results using in silico approaches.
Nesrine Benkhaira, Mohamed El Fadili, Naoufal El Hachlafi, Rhizlan Abdnim, Saad Ibnsouda Koraichi, Kawtar Fikri-Benbrahim, Koteshwara Mudigonda   +6 more
wiley   +1 more source

CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation [PDF]

, 2003
CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation.
Callard, R.E., Inwald, D.P., Klein, N.J., McDowall, A., Peters, M.J.   +4 more
core  

Small-Molecule Screen Identifies Reactive Oxygen Species as Key Regulators of Neutrophil Chemotaxis [PDF]

, 2014
Neutrophil chemotaxis plays an essential role in innate immunity, but the underlying cellular mechanism is still not fully characterized. Here, using a small-molecule functional screening, we identified NADPH oxidase–dependent reactive oxygen species as ...
Blanchard, Catlyn, Hattori, Hidenori, Jia, Yonghui, Jo, Hakryul, Kasorn, Anongnard, Li, Yitang, Loison, Fabien, Luo, Hongbo, McDonald, Douglas Ray, Pai, Sung-Yun, Porter, Timothy F., Sakai, Jiro, Sarraj, Bara, Serhan, Charles Nicholas, Subramanian, Kulandayan K., Zirkle, Dorothy   +15 more
core   +1 more source

Mulberry Leaf Extract and Deoxynojirimycin Modulates Glucose and Lipid Levels via the IRS1/PI3K/AKT Signaling Pathway in Cells

Journal of Food Biochemistry, Volume 2025, Issue 1, 2025.
Various diseases caused by disorders of glucose and lipid metabolism are increasing day by day. Although many drugs have certain therapeutic effects, they still produce some side effects. Therefore, this article chooses the natural medicinal plant mulberry leaves to reveal its mechanism of regulating glucose and lipid metabolism.
Yin-Di Zhang, Jun-Xi Liu, Fei-Fei Wang, Li-Ping Qu, Miguel Rebollo-Hernanz   +4 more
wiley   +1 more source

Selective Protection/Deprotection in 1-Deoxynojirimycin Scaffold: Regioselective Mono-Benzoylation and Alkylation using TBAB-NaOH Catalytic System

Acta Chimica Slovenica, 2018
Protecting groups play an important role in the carbohydrate chemistry and considerably influence the reactivity of substrate. A study of the substitution of various protecting groups in 1-deoxynojirimycin was carried out. Substrate N-benzyloxycarbonyl-1,
Mehwish Iftikhar, Zhijie Fang
doaj   +1 more source

Isomeric Polycyclic Polyprenylated Acylphloroglucinols from the Bark of (Clusiaceae)

Natural Product Communications, 2017
Five new isomeric polycyclic polyprenylated acylphloroglucinols (PPAPs) named mesuaferroic acid A, B, C, E and F ( 1–5 ) were isolated from ethyl acetate extract of Mesua ferrea L. (Clusiaceae).
Nurulfazlina Edayah Rasol, Humera Naz, Khalijah Awang, Mohamad Jemain Mohamad Ridhwan, Yap Ken Choy, Nor Hadiani Ismail   +5 more
doaj   +1 more source

A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells [PDF]

, 2017
Recent advances in fluorescent ligand technology have enabled the study of G protein-coupled receptors in their native environment without the need for genetic modification such as addition of N-terminal fluorescent or bioluminescent tags.
Antonioli, Bain, Baker, Baker, Borea, Cao, Castro, Cohen, Cornelius, Crystal, Dalpiaz, Daly, Dionisotti, Fredholm, Fredholm, Gallo-Rodriguez, Gao, Gherbi, González-Fernández, Guo, Hara, Headrick, Hussain, Iturrioz, Jacobson, Jacobson, Ji, Joshaghani, Kecskes, Klotz, Klotz, Korb, Kozma, Kuder, Li, Little, May, Montinaro, Mulloy, Nakamura, Ohana, Ongini, Ranganathan, Ravani, Squarcialupi, Stoddart, Stoddart, Stoddart, Stoddart, Tomasch, Tosh, Vainio, van Galen, van Muijlwijk-Koezen, Vernall, Vernall, Wu, Yoshida, Young, Zwier   +59 more
core   +1 more source

Effect of 1-epoxyalkyl-1-deoxynojirimycins on exoglucosidases

Tetrahedron, 1991
Abstract The total synthesis of two nojirimycin derivatives 13 and 33 has been achieved. These substances act as inactivators or inhibitors of α- and β-glucosidases.
Louis J. Liotta, Jeehiun Lee, Bruce Ganem   +2 more
openaire   +1 more source