Results 161 to 170 of about 52,551 (253)

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Rethinking ethanol separation in continuous spirit production from a process intensification perspective

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Continuous neutral‐alcohol and food‐grade ethanol production is an energy‐intensive process in which distillation and rectification alone account for 50–85% of total plant energy use. While significant advances in separation technology have emerged over the past two decades, the spirits industry continues to rely predominantly on multi‐effect ...
Anton A Kiss
wiley   +1 more source

Evolution of free amino acids and volatile compounds in dry‐cured fermented 'salchichón' sausages superficially inoculated with different molds

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Surface molds contribute to flavor development in dry‐cured fermented sausages through their effects on proteolysis, amino acid catabolism, and volatile compound formation. This study evaluated the influence of Aspergillus oryzae, Penicillium camemberti, Penicillium roqueforti and Penicillium nalgiovense on the evolution of free ...
José María Martín‐Miguélez, Alberto González‐Mohino, Jorge Ruiz‐Carrascal, Lary Souza Olegario, Josué Delgado   +4 more
wiley   +1 more source

Solvent Mediation of Peptide Conformations: Polyproline Structures in Water, Methanol, Ethanol, and 1-Propanol as Determined by Ion Mobility Spectrometry-Mass Spectrometry. [PDF]

J Am Soc Mass Spectrom, 2019
El-Baba TJ, Fuller DR, Hales DA, Russell DH, Clemmer DE.   +4 more
europepmc   +1 more source

Identification and quality characterization of a putative novel 17x + 8y high‐molecular‐weight glutenin subunit recombination in bread wheat

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND High‐molecular‐weight glutenin subunits (HMW‐GSs) are major determinants of dough rheological behavior and bread‐making quality in bread wheat (Triticum aestivum L.). Among wheat genomes, the Glu‐B1 locus exhibits the highest allelic diversity; however, recombination events between x‐ and y‐type HMW‐GS genes are considered extremely
Nevzat Aydin, Bedrettin Demir, Mehmet Koyuncu, Jan Bocianowski, Aras Türkoğlu   +4 more
wiley   +1 more source

Cider alchemy: investigating the physicochemical and sensory properties of red‐fleshed apple juice and cider

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Red‐fleshed apples (RFAs) offer a distinctive edge in cider production due to their high phenolic content, contributing to unique colors and interesting flavor profiles. However, comprehensive studies on the physicochemical and sensory properties of RFA juices and ciders are limited.
Marbi Schwartz, Dalene de Beer, Marieta van der Rijst, Jeannine Marais   +3 more
wiley   +1 more source

Bio‐Derived Nanophotonic Hybrids Enabling Reconfigurable Upconversion for Multilevel Optical Encryption

Laser &Photonics Reviews, EarlyView.
A dual‐gated nanophotonic platform integrates lanthanide‐doped upconversion nanoparticles with a stimuli‐responsive silk–zirconia photonic crystal to enable multilevel optical encryption. Resonant photonic coupling allows hydration‐dependent modulation of visible emission under near‐infrared excitation, achieving reversible switching between decoy and ...
Taehoon Kim, Seohan Yun, Fiorenzo G. Omenetto, Junyong Park   +3 more
wiley   +1 more source

Wavefront Shaping for Optimal Extinction of Focused Light by Individual Nanoscatterers

Laser &Photonics Reviews, EarlyView.
Wavefront shaping enables near‐complete optical extinction by nanoscatterers separated from a planar reflector. Time‐reversed emission profiles provide optimal illumination conditions, yielding 70% extinction from a single plasmonic nanoparticle and up to 90% from sub‐wavelength nanoparticle clusters, offering a promising route to efficient in‐ and out‐
Nick Feldman, Joris Pals, Arie J. den Boef, F. Javier García de Abajo, Lyubov V. Amitonova, A. Femius Koenderink   +5 more
wiley   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Chronic High‐Dose Ketamine Fails to Induce a Cystitis‐Like Phenotype in Mice Despite High Urinary Metabolite Levels

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims Ketamine‑induced cystitis (KIC) is a severe complication of chronic ketamine misuse, yet the underlying mechanisms remain poorly understood. Established rodent models have demonstrated variable changes in voiding behavior and bladder histology, without exploring the sensory mechanisms underlying altered voiding and pain at all. This study
Jill Dewez, Ashlee Caldwell, Laura Schillebeeckx, Margot De Vis, Sylvia João Poseiro Coutinho Pinto, Evy Van Den Broek, Véronique Hendrickx, Katrien Luyten, Marcella Baldewijns, Jan Tytgat, Thomas Voets, Wouter Everaerts   +11 more
wiley   +1 more source