Results 71 to 80 of about 1,499,618 (334)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Poverty in the Texas borderland and lower Mississippi Delta: A comparative analysis of differences by family type

Demographic Research, 2009
We provide a comparative analysis of county-level poverty in the two poorest regions of the United States - the Texas Borderland and the Lower Mississippi Delta - with a special focus on differences by family type.
Tim Slack, Joachim Singelmann, Kayla Fontenot, Dudley L. Poston, Jr., Rogelio Saenz, Carlos Siordia   +5 more
doaj  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Poverty Papers 1

, 2008
This report is the first in a series of poverty papers published by the Social Policy Research Unit (SPR), Faculty of Social Work, University of Regina. The purpose of the papers is to analyze an aspect of poverty in society and offer various perspectives for change.
Hunter, Garson, Douglas, Fiona, Pedersen, Sarah   +2 more
openaire   +1 more source

Correction to: The Use of a Three-Level M-Quantile Model to Map Poverty at Local Administrative Unit 1 in Poland [PDF]

, 2023

openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Reducing Poverty in California…Permanently [PDF]

, 2015
If California were to seriously commit to equalizing opportunity and reducing poverty, how might that commitment best be realized? This is of course a hypothetical question, as there is no evidence that California is poised to make such a serious ...
Coddou, Marion, Collis, Conway, Cumberworth, Erin, Fisher, Jonathan, Furuta, Jared, Grusky, David, Hill, Jasmine, Kimberlin, Sara, King, Molly M., Kucheva, Yana, Leupp, Ryan, Matosantos, Ana, Powers, Courtney, Rodriguez, Natassia, Sanchez, Sandra, Wright, Rachel   +15 more
core   +1 more source

Researching ‘bogus’ asylum seekers, ‘illegal’ migrants and ‘crimmigrants’ [PDF]

, 2014
Both immigration and criminal laws are, at their core, systems of inclusion and exclusion. They are designed to determine whether and how to include individuals as members of society or exclude them from it, thereby, creating insiders and outsiders ...
A Coffey, AR Hochschild, F Yuen, G Hubbard, JH Watts, L Fekete, L Rew, L Weber, R Wilkins, S Mintz   +9 more
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source