Results 51 to 60 of about 17,541,326 (249)
Childhood-Onset Systemic Lupus Erythematosus in Southwestern Iran: A Clinical and Serological Study
The Turkish Journal of Gastroenterology, 2014 Objectives: This study aims to describe clinical manifestations of systemic lupus erythematosus (SLE) and laboratory assessment in children in the Southwestern Iran.
Soheila ALYASIN +5 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 1994 介绍ＡＢＡ－１００型自动生化分析仪测定血中果糖胺的方法，对能引起果糖胺值波动，且在各实验室使用不一致的某些反应条件（如温度、比色时间、显色剂浓度、样品与试剂体积比等）进行了观察与分析。利用此法测定果糖胺，方法线性良好，批内与批间变异系数分别为１．３２％和２．４１％，回收率平均为９７％，优于手工测定，成人血清果糖胺的正常参考值（ｘ±ｓ）为２．２４±０．２６ｍｍｏｌ／Ｌ（１．７～２．８ｍｍｏｌ／Ｌ，ｎ＝１４４），与国外多数报道近似．
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Shiyou jixie, 2014 为配套海上采油平台而设计了2 250 kN海洋钻修机模块。2 250 kN海洋钻修机模块在设计上充分满足平台布局要求紧凑性和模块化的要求，采用联合驱动的传动系统设计也满足用户对钻机模块经济性的要求。井架结构设计打破常规，采用从基段两侧进钻杆的方案及自升式结构，可满足钻机在不同区位作业的便捷性要求。绞车采用交流变频联合驱动的传动形式，底座采用大模块化的结构形式，从而满足CEPI和CEPJ固定式采油平台钻机作业区域小和移动跨距大的需求。该钻机设计中采用的一些新方法可降低固定式平台钻修机模块的建造成本 ...
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Shiyou jixie, 2014 加大隔水管处理系统技术研究力度，快速实现该系统的国产化对推动我国海洋石油装备的全面发展意义深远。在介绍国内、外隔水管处理系统发展现状的基础上，对隔水管处理系统进行了技术分析，主要包括卧式隔水管处理系统和立式隔水管处理系统，并将两者进行了对比，其主要不同为存储方式对平台结构的影响、工作效率与安全性、隔水管移运吊机和存储指梁。我国要开发具有自主知识产权的隔水管处理系统，需攻克的关键技术有隔水管移运载荷分析、控制系统设计及系统安全性设计。建议我国从立式隔水管处理系统入手，研究试制其重要单元设备 ...
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Shiyou jixie, 2014 针对现有的偏心分注工具不能满足薄互层油藏小卡距细分注水、原K344型偏心封隔配水器不适应大斜度注水井分注的问题，研制了P2Y341-115型细分层封隔配水器。该工具将1个压缩式封隔器与2台偏心配水器的功能集成一体，实现多个连续薄夹层注水井的分注，并大幅提高测试调配效率。现场应用7口井，封卡最薄油层4.4 m，最大井斜31.75°，均完成了分层验封、分层流量测试及水嘴投捞，平均配注符合率达到89.8%，平均使用寿命达到1 a以上。
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source