Results 71 to 80 of about 17,541,326 (249)
Shiyou jixie, 2015 卡箍式水下连接器稳定的着陆过程将有效减小着陆时连接器对密封圈的冲击，进而避免密封失效。通过Matlab仿真软件对连接器缓冲机构进行建模，针对其关键环节进行多参数模拟。模拟结果表明，由液压系统组成的缓冲机构能够有效起到缓冲连接器平稳着陆的效果，相比没有缓冲机构的连接器着陆时的冲击减小90%；缓冲机构中节流阀对缓冲机构液压系统起到了保证压力平稳的作用，当其开度为200 mm2时缓冲效果最好，稳定时间缩短70%；减压阀能够有效降低接触时液压系统的压力峰值，当调定压力为20 ...
doaj
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Shiyou jixie, 2014 基于水下卧式采油树使用工况和结构特点，确定了水下采油树静水压试验方案，完成了水下卧式采油树静水压试验装置设计和关键结构设计，在此基础上拓展了试验装置的功能和用途。该试验装置具备采油树静水压试验时所需的连接、密封、承载等功能，装置中螺纹式连接接头可用于金属密封垫环预紧力的测试，建立的金属密封垫环工作内压与预紧力之间的对应关系可用于研究海洋水下设备之间金属密封垫环的连接、挤压、变形和密封等问题，从而为现场使用提供参考依据。
doaj
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Shiyou jixie, 2014 国内连续管作业机虽然已经有了较大的发展，但是国内开发的相关软件功能模块比较单一，大部分连续管作业配套软件基本依靠国外公司开发的相关产品。介绍了4种国外连续管作业软件现状，并对其软件架构进行深入分析，认为一个完整的综合作业软件应该有几个应用模块：①数据采集模块。采集并监控作业关键参数，为力学模拟、流体模拟和疲劳评估提供基础数据。②力学模拟模块。对连续管管柱的力和应力进行综合模拟，并由此模拟作业过程中各种因素对作业的影响，可以进行作业前设计或实时监控作业过程。③流体模拟模块。对连续管及井筒内的流体进行模拟 ...
doaj
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Shiyou jixie, 2014 自动液压动力卡瓦是井口机械自动化的重要一环。介绍了液压动力卡瓦的产品分类及特点，概述了液压动力卡瓦技术发展现状，尤其对当前NOV、B+V以及Weatherford公司的典型液压动力卡瓦的结构参数和性能特点进行了重点分析研究。最后指出了液压动力卡瓦的发展趋势：①向承载多样化，夹持多元化方向发展；②向高安全性、高可靠性方向发展；③向控制操作智能化、集成化方向发展。
doaj
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Shiyou jixie, 2015 涡轮钻具轴承组在恶劣的工作环境中受到钻压、水力载荷以及钻进冲击与振动的作用，容易发生磨损现象，直接影响涡轮钻具的使用寿命。以φ127 mm涡轮钻具为例，根据弹塑性力学和赫兹接触理论，运用ABAQUS软件建立定子－滚珠－转子非线性接触问题有限元模型，针对不同磨损程度的滚珠轴承进行了数值模拟分析。研究结果表明，随磨损量的增大，轴承定子、转子与滚珠的接触面积逐渐减小，应力集中现象加剧，接触应力明显增大；最大接触应力出现在滚珠上，且与磨损量呈现非线性关系；相同工况下，磨损2 ...
doaj
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source