Results 81 to 90 of about 17,541,326 (249)

水平井作业机器人分布式控制系统设计

open access: yesShiyou jixie, 2015
针对水平井作业机器人的结构特点,采用分布式结构理论,设计了基于PIC18F2620微控制器的1个上位机和多个分布式下位机的2层分布式控制系统。上位机通过电力线向下位机发送控制指令,控制相应的下位机控制模块完成特定的功能,同时实时接收下位机反馈的状态监测参数,并在人机交互界面上实时显示和判断水平井作业机器人的工作状态;上位机与下位机之间采用电力线载波通信技术实现电力传输和数据通信。通信试验和综合测试结果表明,水平井作业机器人分布式控制系统运行稳定,通信实时性强,满足水平井作业机器人的控制要求。
, 1
doaj  

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

投球滑套双锥度球座的冲蚀磨损优化研究

open access: yesShiyou jixie, 2015
水平井裸眼完井分段压裂技术是现阶段提高低渗透油藏产能的主要技术,其技术难点在于分段压裂工具的密封可靠性,其中投球滑套的密封性能在很大程度上直接决定分段压裂的成败,导致投球滑套密封失效的主要原因则是流体携砂冲蚀。依据投球滑套球座的实际工况,在常规单锥度球座的基础上提出双锥度球座,并借助Fluent流体软件实现对双锥度球座的结构优化,优化后的球座二锥度应介于70°~80°之间。双锥度球座解决了由于球座冲蚀磨损造成的投球滑套密封失效问题,保证了水平井裸眼完井分段压裂的可靠性。
, 1, 2
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

热敏封隔器坐封力数值分析

open access: yesShiyou jixie, 2015
热敏封隔器的坐封力较小,容易在上、下 压差的作用下产生滑移,导致伸缩管闭合,造成热膨胀无法补偿而损坏封隔器。鉴于此,采用ANSYS对热敏封隔器的坐封过程进行模拟计算,分析结果表明,热敏封隔器在注气压力15.00 MPa、温度200 ℃下坐封后,最大应力出现在动力件上,其值为413.00 MPa;密封筒与套管接触应力分布呈马鞍状,中部应力有极小值;当注气温度高于200 ℃以后,接触应力随温度的升高增长缓慢;在200 ℃、15.00 MPa注气工况下需要将套压控制在11.43 MPa以上 ...
, 1, 2
doaj  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

新型注水井除垢器的设计与研制

open access: yesShiyou jixie, 2014
针对目前注水井油管除垢作业存在处理成本高及程序繁琐等问题,研制了一种新型注水井除垢器。该除垢器采用涡轮驱动,在动力液作用下,涡轮转子旋转并通过主轴带动磨铣装置转动,对油管结垢进行逐层切削,除垢作业完成后,在反冲液的作用下使其内部单向阀关闭,并反向上行至井口,无需打捞工具打捞。该除垢器可自行在井下对油管结垢进行清除,无需人力,解决了现有除垢方法效率低的问题,大大降低了作业成本,提高了油田的综合效益,并且该除垢器结构简单,使用方便,除垢效果好,具有广阔的推广应用前景。根据现场应用结果分析 ...
, 〓, 1, 2
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

产品生命周期成本视角的海底电缆采购管理模式

open access: yesShiyou jixie, 2014
在介绍现有海底电缆采购模式的基础上,分析了以邀请招标和最低评标价法为主的采购管理模式存在的弊端。从用户视角和企业视角分析了海底电缆产品的生命周期成本,指出海底电缆生命周期成本需考虑的因素包括新产品研发投入、核心资源要素、核心技术要素、售后服务水平及供需对接供应商。最后提出了采购管理模式的改进措施,具体包括:开发电缆成本测算软件,规避恶性价格竞争;使用综合评价法,合理确定采购成本;针对其他成熟产品,逐步形成“主材+辅材+管理费”的定价机制;对供应商进行全面绩效评估,关注产品生命周期成本。
, 1, 3
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy