Results 101 to 110 of about 10,948,837 (276)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Palau 100 2016-2017

, 2018
Programa general de la Temporada 2016-2017 del cicle ""Palau 100"

core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Nota Editorial 100

Desarrollo y Sociedad
Nota del Editor de Desarrollo y Sociedad Ignacio Sarmiento-Barbieri sobre nuestro número 100.
Ignacio Sarmiento-Barbieri
doaj   +1 more source

Palau 100 2015-2016

, 2018
Programa general de la Temporada 2015-2016 del cicle ""Palau 100"
Fundació Orfeó Català-Palau de la Música
core  

The Future of Transportation and Urban Planning: A California 100 Report on Policies and Future Scenarios [PDF]

Nearly every aspect of social, economic, and political life in California is linked by its transportation systems. These systems can be seamless and somewhat transparent when they work well, but their failings can be glaring and deeply problematic when ...
Pinski, Miriam, University of California, Los Angeles. Institute of Transportation Studies, Mutate, Juan, Ding, Hao, Rios Gutierrez, Alejandra, Garrett, Mark, Gahbauer, John, Wasserman, Jacob L, Taylor, Brian D., Rios Gutierrez, Nataly, California 100   +10 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Records of Katherine Anne Porter at 100

, 1989
Katherine Anne Porter at 100: New Perspectives was a public program funded by the National Endowment for the Humanities. The University of Maryland, College Park, was the site of this celebration of the hundredth birthday of Katherine Anne Porter, May 9 ...
Porter, Katherine Anne at 100, Records
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source