Results 31 to 40 of about 1,617,748 (250)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
102-Plex Approach for Accurate and Multiplexed Proteome Quantification
Hyperplexing approaches have been aimed to meet the demand for large-scale proteomic analyses. Currently, the analysis capacity has expanded to up to 54 samples within a single experiment by utilizing different isotopic and isobaric reagent combinations.
Xumin Zhang (698351) +3 more
core +3 more sources
Open Veterinary JournalBackground: Canine obesity is an increasingly concerning issue that negatively impacts dogs' health, quality of life, and lifespan. Aim: This study aimed to evaluate the adipokine profiles of overweight and obese dogs and their associations with ...
Adrian Carzoli +2 more
doaj +1 more source
Editorial Enletawa Journal 10.2
Enletawa Journal, 2018 This new edition of ENLETAWA JOURNAL includes articles on how communication is carried out in the EFL classroom, as well as the use of literature to foster foreign language learning.
Yuranny Marcela Romero Archila
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Open Veterinary JournalBackground: Staphylococcus aureus is an opportunistic pathogen widely present in humans and food-producing animals. The emergence of antimicrobial resistance (AMR) in S. aureus represents a major challenge for both animal and public health. Aim: This
Nguyen Van Chao +4 more
doaj +1 more source