Results 41 to 50 of about 8,417,214 (287)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The enormous outer Galaxy HII region CTB 102
, 2009 We present new radio recombination line observations of the previously unstudied HII region CTB 102. Line parameters are extracted and physical parameters describing the gas are calculated. We estimate the distance to CTB 102 to be 4.3 kpc.
Basu +14 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Open Veterinary JournalBackground: Canine obesity is an increasingly concerning issue that negatively impacts dogs' health, quality of life, and lifespan. Aim: This study aimed to evaluate the adipokine profiles of overweight and obese dogs and their associations with ...
Adrian Carzoli +2 more
doaj +1 more source
Editorial Enletawa Journal 10.2
Enletawa Journal, 2018 This new edition of ENLETAWA JOURNAL includes articles on how communication is carried out in the EFL classroom, as well as the use of literature to foster foreign language learning.
Yuranny Marcela Romero Archila
doaj +1 more source
, 2003 The purpose of this resource is to develop an understanding of some of the relationships between soils of different types and water. Students will time the flow of water through soils with different properties and measure the amount of water held in ...
The GLOBE Program, University Corporation for Atmospheric Research (UCAR)
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source