Results 41 to 50 of about 1,617,748 (250)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Targeting the HERV-K102 envelope elicits pyroptosis and represents a novel therapeutic strategy for acute myeloid leukemia

Blood Research
Objective Several recent studies have focused on human endogenous retroviruses (HERVs). HERVs entered the human genome millions of years ago and are associated with various diseases including cancer and immune regulation.
Lihong Zong, Qian Luo, Jingru Zhao, Huyi Lei, Hui Liu, Mengyuan Li, Yiyuan Chen, Minghuan Zhang, Rongzhen Xu, Wenbin Qian   +9 more
doaj   +1 more source

Interaction of vitamin B1 and phenylalanine on the pharmacokinetics of ciprofloxacin using bioassay in rabbits

Indian Journal of Animal Sciences
This pharmacokinetic study was carried out in rabbits following single oral administration of ciprofloxacin to study kinetic behaviour of ciprofloxacin in the presence of vitamin B1 and selected essential amino acid phenylalanine.
P ANJANEYULU, K V VENKATA RAO, SRIVIDYA GULLAPUDI, K ASWANI KUMAR, V SRI HARSHINI, G SAI PRATHYUSHA, G S RAO, SUMA SRI TIMMAREDDY   +7 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Soft tabletting of MCC 102 and UICEL-A/102 pellets into multiple unit pellet systems [PDF]

, 2009
Multiple Unit Pellet Systems, widely known as MUPS, are tablets consisting of spherical, granular subunits (pellets). Thanks to their prompt disintegration into the single subunits immediately after administration, they transit shortly in stomach and ...
Balzano, Vincenzo
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

102 Dúo (Colombia)

, 2001
Concierto interpretado por 102-Dúo. Creado en 1999 en el departamento de música de la Universidad Javeriana. El dúo ha trabajado bajo la dirección de Ricardo Jaramillo, Georg Meerwin y Enrique Ardila.
102 Dúo (Colombia)
core  

Next Level Quotas? Corporate and Public Support for Gender Quotas in Executive Management

Administrative Sciences
This study provides the first comprehensive examination of gender quota legislation for executive management positions, executive gender quotas (EGQs), in Icelandic listed companies, alongside the general public’s attitudes toward such measures.
Ásta Dís Óladóttir, Thora H. Christiansen, Haukur Freyr Gylfason, Haukur C. Benediktsson, Freyja Vilborg Thorarinsdottir   +4 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

L'audit energetico nella Pubblica Amministrazione secondo il Decreto legislativo 102/2014 [PDF]

, 2022
Linee guida che descrivono la procedura tecnico-amministrativa con cui viene redatto un audit energetico nella Pubblica Amministrazione, in relazione al Decreto 102 ...
Zulini, Luca
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