Results 61 to 70 of about 367,991 (224)
Use of designed sequences in protein structure recognition
Biology Direct, 2018 Background Knowledge of the protein structure is a pre-requisite for improved understanding of molecular function. The gap in the sequence-structure space has increased in the post-genomic era.
Gayatri Kumar +3 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Indian Journal of Animal Sciences, 2020 Brucellosis is a well-known and wide spread zoonotic disease. It is endemic in several parts of Asia, including India. In this study, seroprevalence of porcine brucellosis was studied among apparently healthy pigs in Meghalaya where pig keeping plays a ...
INGUDAM SHAKUNTALA +10 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Indian Journal of Agricultural Sciences, 2014 Thirty four pole type French bean (Phaseolus vulgaris L.) genotypes were evaluated to assess their genetic variability to identify desirable ones for yield and quality traits. The genotypic variance was moderate to high for the all the 14 traits studied,
VEERENDRA KUMAR VERMA +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Asian Journal of Pharmaceutical Sciences, 2017 A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative (2'-deoxy-2', 2'-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl amm-onio) butanoate-cytidine, JDR) in rat plasma was developed and ...
Gang Wang +12 more
doaj +1 more source
Nature Communications, 2016 MicroRNAs regulate the maladaptation of endothelial cells (ECs) to naturally occurring disturbed blood flow at arterial bifurcations resulting in arterial inflammation and atherosclerosis in response to hyperlipidemic stress.
P. Hartmann +9 more
semanticscholar +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Algorithms for Optimizing Vocabulary Acquisition in Language Learning
Proceedings of the International Conference on Applied Innovations in ITThis study addresses the critical role of dictionaries in language learning, emphasizing the need for effective navigation strategies to enhance vocabulary acquisition.
Tetiana Verhun +5 more
doaj +1 more source