Results 101 to 110 of about 344,271 (239)

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Minimum Service Standar (MSS) For Basic Education in Musi Rawas Regency

Edukasi Islami: Jurnal Pendidikan Islam
Implementation of Minimum Service Standard (MSS) in basic education is one of the indicators the success of development in education. Each regency with its authority carries out the program to support the Minimum Service Standard of basic education. This
Hartoyo Hartoyo, Sudarwan Danim
doaj  

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

國中教師以學習共同體啟動新學習型態之研究 Adopting a Learning Community in a Junior High School under the 12-Year Basic Education System

Journal of Research in Education Sciences, 2014
近來，佐藤學「學習共同體」的課堂改革論述，在許多亞洲國家（如日本、韓國、中國大陸）掀起了學習革命。而臺灣正因應十二年國民基本教育，學校現場展開了課程教學轉化的實踐。若干縣市已啟動學習共同體的教育政策，鼓勵學校因應十二年國民基本教育啟動教室中的學習革命，為下一代學習開展了轉化的新契機。本研究首先闡述佐藤學「學習共同體」在課堂教學與學習的重要論述；其次探討過去國中生長久以來在升學競爭下形成的被動學習與逃離學習的現象；最後採質性研究的方式，以任教於不同國中的五科專任教師（國文、英文、數學、自然、社會）為訪談對象，探究其以學習共同體啟動課程教學革新的經驗。研究者由訪談結果發現了其教學方式的改變，這些教師也看到了學生學習的改變。本研究的重要發現有六： 一、當前國中教師是以較綜合多元的方式推動課堂學習共同體 ...
openaire   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

High‐Throughput Screening and Interpretable Machine Learning for Rational Design of Bimetallic Catalysts for Methane Activation

Advanced Science, EarlyView.
ABSTRACT Methane's efficient catalytic removal is vital for sustainable development. Bimetallic catalysts, though promising for methane activation, pose a design challenge due to their complex compositional space. This work introduces an integrated framework that combines high‐throughput density functional theory (DFT) and interpretable machine ...
Mingzhang Pan, Tian Zhang, Jiawei Dong, Yubao Xie, Kaifeng Zhong, Wei Guan, Haiqiao Wei, Changcheng Fu, Yaqiong Su   +8 more
wiley   +1 more source

Advances and Perspectives in Graphene‐Based Quantum Dots Enabled Neuromorphic Devices

Advanced Science, EarlyView.
Graphene‐based QDs are zero‐dimensional carbon nanomaterials with pronounced quantum confinement and tunable electronic structures. Herein, we summarize their synthesis strategies and functionalization methods, and highlight their functional roles and operating mechanisms in devices, as well as recent advances in neuromorphic electronics. We anticipate
Yulin Zhen, Wei Zeng, Zherui Zhao, JiYu Zhao, Ziyan Huang, Zhuo Chen, Kui Zhou, Guanglong Ding, Su‐Ting Han, Ye Zhou   +9 more
wiley   +1 more source

從大學的發展趨勢探析十二年國民基本教育普通高中階段的課程改革 From the Development Trend of University to Study High School Curriculum Reform of 12-year Basic Education

Journal of Curriculum Studies, 2013
大學階段的人才培育是教育的重要課題，而它與普通高中教育有著密不可分的連動關係。隨著大學數量的擴增、全球化競爭與知識經濟之趨勢，大學教育已從菁英教育朝向大眾化教育，並且人才培育觀也從強調專精專門知識的人才培養轉而強調具備通識、跨領域能力及公民素養的全人教育觀。大學教育的這些轉變與發展，將連動高中教育的定位與課程改革，包括重新定位普通高中的通識教育功能、強化跨領域學科能力、公民素養的培養，以及如何與大學端的優質銜接等。本研究係在此脈絡下，首先說明大學發展趨勢及人才培育觀的轉變，其次探討現行普通高中教育，特別是課程綱要及學校課程在此方面的回應、連動影響與相關現況。最後，則針對未來十二年國民基本教育普通高中階段之課程改革提出若干建議。 The increase in the number of ...
openaire   +1 more source