Results 81 to 90 of about 363,095 (169)

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

Dual Repression by IPA1 Fine‐Tunes OsbZIP79‐Mediated Salt Tolerance in Rice

Advanced Science, EarlyView.
Dual repression by IPA1 fine‐tunes OsbZIP79‐mediated salt tolerance in rice: direct transcriptional inhibition under normal conditions and salt‐induced degradation under stress. This dual mechanism activates OsbZIP79 to regulate Na+/K+ homeostasis and redox balance via downstream genes, enabling optimal salt stress response.
Hui Wang, Bo Liu, Can Hu, Chenfan Zheng, Yuting Wei, Xier Xu, Wei Yang, Yu Fang, Guangle Shen, Pedro García‐Caparros, Conghe Zhang, Qingyao Shu, Meng Jiang   +12 more
wiley   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Teaching and training of anaesthesia and critical care technicians in India - Towards a competency-based modular framework. [PDF]

Indian J Anaesth
Shukla A, Chaurasiya MK, Gautam S, Singh P, Mishra NK, Kohli M.   +5 more
europepmc   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Where Are the Women in Basic Science Research? Gender Trends in Abstracts Presented at the Academic Surgical Congress. [PDF]

J Surg Res
Obidike PC, Washington TE, Lee T, Williams GF, Jones TC, Fritz A, Cheng LS.   +6 more
europepmc   +1 more source

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

Barriers to oral healthcare for autistic children in China. [PDF]

Front Psychiatry
Wang X, Huang X.
europepmc   +1 more source

Optimized Land–Water Management Expands Afforestation Potential Under Land and Human Water‐Use Constraints

Advanced Science, EarlyView.
Human water demand constrains China's feasible afforestation potential more strongly than is commonly recognized, and future climate change further intensifies this limitation. Integrating land‐use optimization with water‐saving measures substantially expands feasible afforestation area and associated carbon sinks, revealing a practical pathway to ...
Binbin Huang, Fei Lu, Yuebo Su, Xuming Wang, Hua Zheng, Zhiyun Ouyang   +5 more
wiley   +1 more source

The Japanese orthopaedic association at one hundred: a century of Japanese orthopaedics. [PDF]

Int Orthop
Nakashima Y, Kawano H.
europepmc   +1 more source