Results 21 to 30 of about 107,996 (262)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Estimation of polycyclic aromatic hydrocarbons (PAHs) emission and its toxicity potentials from the combustion of selected fuelwoods

Case Studies in Chemical and Environmental Engineering
In many developing nations, wood is still commonly used as a fuel for domestic cooking. However, fuelwood combustion can have a pronounced effect on air quality by releasing considerable level of PAHs, thereby posing serious risk to global and ...
Ebenezer Leke Odekanle, Royal Oghosasere Taiwo, Jacob Ademola Sonibare, Adenike Omowumi Akinyemi, Timothy Adesoye Adekanye, Bamidele Sunday Fakinle   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Predictive Assessment of Climate Change Impact on Water Yield in the Meta River Basin, Colombia: An InVEST Model Application

Hydrology
This paper presents a hydrological assessment of the 113,981 km2 Meta River basin in Colombia using 13 global climate models to predict water yield for 2050 under two CMIP6 scenarios, SSP 4.5 and SSP 8.5.
Jhon B. Valencia, Vladimir V. Guryanov, Jeison Mesa-Diez, Nilton Diaz, Daniel Escobar-Carbonari, Artyom V. Gusarov   +5 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Multidirectional paths to achieve the SDG-13 from Mexican universities: interdisciplinary, sustainable lifestyles and green technology

Ciencias Administrativas Teoría y Praxis
This paper aimed to analyze the climate actions of Mexican universities to identify the multidirectional paths that would allow the strategic reorganization to foster to the achievement of SDG 13 (climate action).
Lorena del Carmen Álvarez-Castañón, Pilar Arroyo-López, Daniel Tagle-Zamora   +2 more
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Behavioural drivers and barriers for adopting climate mitigation actions on dairy farms

Advancements in Agricultural Development
The adoption of climate mitigation actions on farms has the potential to lessen the effects of climate change on agriculture. The purpose of this study is to identify the behavioural drivers and barriers for adopting climate mitigation actions on dairy ...
Niamh Dunphy, Seamus Kearney, Sinéad Flannery   +2 more
doaj   +1 more source

An Appraisal of Nigeria’s Progress in Achieving the SDG-13 Climate Action Goal

Journal of Sustainable Development, 2022
The impacts of climate change on the planet are increasingly felt with projections suggesting even greater impacts in the immediate term and, as such, the need for concerted efforts directed at curbing them. Although Nigeria battles with huge development needs, and its economy is confronted with a rapidly deteriorating fiscal space and rising levels of
Salamatu J. Fada, Elijah A. Akintunde, Simi S. Goyol, Nankap L. Binbol, Leonard Bombom, Daniel D. Dabi, Gideon Baklit, Christian Y. Oche   +7 more
openaire   +2 more sources

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source