Results 31 to 40 of about 1,333,018 (308)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Predictive Assessment of Climate Change Impact on Water Yield in the Meta River Basin, Colombia: An InVEST Model Application

Hydrology
This paper presents a hydrological assessment of the 113,981 km2 Meta River basin in Colombia using 13 global climate models to predict water yield for 2050 under two CMIP6 scenarios, SSP 4.5 and SSP 8.5.
Jhon B. Valencia, Vladimir V. Guryanov, Jeison Mesa-Diez, Nilton Diaz, Daniel Escobar-Carbonari, Artyom V. Gusarov   +5 more
doaj   +1 more source

Transformations to achieve the Sustainable Development Goals Includes the SDG Index and Dashboards. Sustainable Development Report 2019 [PDF]

, 2019
The Sustainable Development Report 2019 presents an updated SDG Index and Dashboards with a refined assessment of countries’ distance to SDG targets. The report has been successfully audited for the first time by the European Commission Joint Research ...
Fuller, G., Kroll, C., Lafortune, G., Sachs, J., Schmidt-Traub, G.   +4 more
core  

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

A comparison of different methods of identifying publications related to the United Nations Sustainable Development Goals: Case study of SDG 13—Climate Action [PDF]

, 2022
Philip J. Purnell
  +5 more sources

Multidirectional paths to achieve the SDG-13 from Mexican universities: interdisciplinary, sustainable lifestyles and green technology

Ciencias Administrativas Teoría y Praxis
This paper aimed to analyze the climate actions of Mexican universities to identify the multidirectional paths that would allow the strategic reorganization to foster to the achievement of SDG 13 (climate action).
Lorena del Carmen Álvarez-Castañón, Pilar Arroyo-López, Daniel Tagle-Zamora   +2 more
doaj   +1 more source

Implementation of Sustainable Development Goals Through the Equimarginal Principle and Circular Economy

İstanbul İktisat Dergisi, 2020
Limiting global warming to 1.5o Celsius is the goal set by the Intergovernmental Panel on Climate Change for avoiding catastrophic and irreversible consequences.
Konuralp Pamukçu
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Behavioural drivers and barriers for adopting climate mitigation actions on dairy farms

Advancements in Agricultural Development
The adoption of climate mitigation actions on farms has the potential to lessen the effects of climate change on agriculture. The purpose of this study is to identify the behavioural drivers and barriers for adopting climate mitigation actions on dairy ...
Niamh Dunphy, Seamus Kearney, Sinéad Flannery   +2 more
doaj   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source