Results 51 to 60 of about 1,315,727 (319)

Crecimiento económico inclusivo y sostenible en la Agenda 2030: un análisis crítico desde la perspectiva de la soberanía alimentaria y los derechos de la naturaleza [PDF]

Revista Iberoamericana de Estudios de Desarrollo, 2020
In the article, it is discussed the objective of «Economic Growth and Decent Work» (SDG 8) of the 2030 Agenda, where it is associated growth with inclusion and environmental sustainability, in its intersection with SDG 2 (eradication of hunger) and SDG ...
Isabella GIUNTA, Javier DÁVALOS
doaj   +1 more source

Achieving food security in the face of climate change: Final report from the Commission on Sustainable Agriculture and Climate Change [PDF]

, 2014
To bring our interconnected food and climate systems within a ‘safe operating space’ for people and the planet, the Commission on Sustainable Agriculture and Climate Change has outlined seven major areas for policy action. Throughout 2011, the Commission
Asaduzzaman, Mohammed, Beddington, J.R., Bo, NV, Clark, Megan E., Erda, Lin, Fernández, A., Guillou, Marion, Jahn, Molly M., Mamo, Tekalign, Nobre, Carlos A., Scholes, Robert J., Sharma, Rita, Wakhungu, Judi W.   +12 more
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

The central role of climate action in achieving the United Nations' Sustainable Development Goals

Scientific Reports, 2023
Sustainable Development Goal (SDG) 13 refers to “Climate Action”. It is one of the 17 goals established by the United Nations in their 2030 Agenda for Sustainable Development.
Walter Leal Filho, Tony Wall, Amanda Lange Salvia, Maria Alzira Pimenta Dinis, Mark Mifsud   +4 more
doaj   +1 more source

Introduction to Ethics: An Open Educational Resource, collected and edited by Noah Levin [PDF]

, 2019
Collected and edited by Noah Levin Table of Contents: UNIT ONE: INTRODUCTION TO CONTEMPORARY ETHICS: TECHNOLOGY, AFFIRMATIVE ACTION, AND IMMIGRATION 1 The “Trolley Problem” and Self-Driving Cars: Your ...
Davies, Benjamin, Grob, Kristina, Jacko, Jan F., Levin, Noah, Nobis, Nathan, Salazar, Eduardo, Seemuth Whaley, Kristin, Singh, Prabhpal, Spelman, Jonathan, Stanton, Elizabeth Cady, Svolba, David, Wooldridge, Brandon   +11 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Social media enables people-centric climate action in the hard-to-decarbonise building sector

Scientific Reports, 2022
The building and construction sector accounts for around 39% of global carbon dioxide emissions and remains a hard-to-abate sector. We use a data-driven analysis of global high-level climate action on emissions reduction in the building sector using 256 ...
Ramit Debnath, Ronita Bardhan, Darshil U. Shah, Kamiar Mohaddes, Michael H. Ramage, R. Michael Alvarez, Benjamin K. Sovacool   +6 more
doaj   +1 more source

Going beyond two degrees? The risks and opportunities of alternative options [PDF]

, 2013
Since the mid-1990s, the aim of keeping climate change within 2 °C has become firmly entrenched in policy discourses. In the past few years, the likelihood of achieving it has been increasingly called into question.
Adger, Neil, Anderson, Kevin, Bows, Alice, Bows-Larkin, Alice, Jordan, Andrew, Joshi, Manoj, Mander, Sarah, Quéré, Corinne Le, Rayner, Tim, Schroeder, Heike, Vaughan, Nem, Whitmarsh, Lorraine   +11 more
core   +1 more source