Results 51 to 60 of about 1,309,182 (315)

Crecimiento económico inclusivo y sostenible en la Agenda 2030: un análisis crítico desde la perspectiva de la soberanía alimentaria y los derechos de la naturaleza [PDF]

Revista Iberoamericana de Estudios de Desarrollo, 2020
In the article, it is discussed the objective of «Economic Growth and Decent Work» (SDG 8) of the 2030 Agenda, where it is associated growth with inclusion and environmental sustainability, in its intersection with SDG 2 (eradication of hunger) and SDG ...
Isabella GIUNTA, Javier DÁVALOS
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Decarbonisation of manufacturing operations: a case study in automotive manufacturing

Production and Manufacturing Research: An Open Access Journal
In response to the climate crisis, companies are increasingly committed to lowering their emissions. Previous studies have investigated climate mitigation strategies in carbon-intensive industries.
Andreas Serino Olander, Lucas Albuquerque Wolf, Lena Moestam, Mélanie Despeisse   +3 more
doaj   +1 more source

Achieving food security in the face of climate change: Final report from the Commission on Sustainable Agriculture and Climate Change [PDF]

, 2014
To bring our interconnected food and climate systems within a ‘safe operating space’ for people and the planet, the Commission on Sustainable Agriculture and Climate Change has outlined seven major areas for policy action. Throughout 2011, the Commission
Asaduzzaman, Mohammed, Beddington, J.R., Bo, NV, Clark, Megan E., Erda, Lin, Fernández, A., Guillou, Marion, Jahn, Molly M., Mamo, Tekalign, Nobre, Carlos A., Scholes, Robert J., Sharma, Rita, Wakhungu, Judi W.   +12 more
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The central role of climate action in achieving the United Nations' Sustainable Development Goals

Scientific Reports, 2023
Sustainable Development Goal (SDG) 13 refers to “Climate Action”. It is one of the 17 goals established by the United Nations in their 2030 Agenda for Sustainable Development.
Walter Leal Filho, Tony Wall, Amanda Lange Salvia, Maria Alzira Pimenta Dinis, Mark Mifsud   +4 more
doaj   +1 more source

Allocating the Burdens of Climate Action: Consumption-Based Carbon Accounting and the Polluter-Pays Principle [PDF]

, 2018
Action must be taken to combat climate change. Yet, how the costs of climate action should be allocated among states remains a question. One popular answer—the polluter-pays principle (PPP)—stipulates that those responsible for causing the problem should
A Agarwal, A Gosseries, A Kander, C Armstrong, CM Duarte, D Bell, D Jamieson, D Jamieson, D Moellendorf, D Moellendorf, Dieter Lüthi, E Kingston, E Neumayer, EA Page, EA Page, G Peters, G Peters, G. P. Peters, Gail Whiteman, H Shue, H Shue, K Steininger, K Steininger, M Lenzen, M Rendall, M Weitzman, MA Delucchi, P Baer, P Baer, R Eckersley, R Schüssler, Rachel James, S Barrett, S Caney, S Caney, S Caney, S Caney, S Caney, Saleemul Huq, SJ Davis, SM Gardiner, SM Gardiner, Susanne Droege, T Athanasiou, T Brooks, WD Nordhaus   +45 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Social media enables people-centric climate action in the hard-to-decarbonise building sector

Scientific Reports, 2022
The building and construction sector accounts for around 39% of global carbon dioxide emissions and remains a hard-to-abate sector. We use a data-driven analysis of global high-level climate action on emissions reduction in the building sector using 256 ...
Ramit Debnath, Ronita Bardhan, Darshil U. Shah, Kamiar Mohaddes, Michael H. Ramage, R. Michael Alvarez, Benjamin K. Sovacool   +6 more
doaj   +1 more source