Results 91 to 100 of about 35,774 (283)

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Integration of a constraint-based metabolic model of Brassica napus developing seeds with 13C-Metabolic Flux Analysis

Frontiers in Plant Science, 2014
The use of large-scale or genome-scale metabolic reconstructions for modeling and simulation of plant metabolism and integration of those models with large-scale omics and experimental flux data is becoming increasingly important in plant metabolic ...
Jordan eHay, Hai eShi, Nicolas eHeinzel, Inga eHebbelmann, Hardy eRolletschek, Jörg eSchwender   +5 more
doaj   +1 more source

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging

Advanced Science, EarlyView.
Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika, Luca Nagel, Ulrike Höckendorf, Bangwen Xie, Geoffrey J. Topping, Mathias Schillmaier, Irina Beer, Frits H. A. van Heijster, Julian Rauch, Tristan A. Kuder, Sandra Sühnel, Bernd Erber, Christian Lohrmann, Simone Ballke, Thomas Metzler, Katja Steiger, Philipp J. Jost, Natalia P. Ivleva, Philipp Paprottka, Jonathan Nadjiri, Kevin M. Brindle, Wolfgang A. Weber, Franz Schilling   +22 more
wiley   +1 more source

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

Quantifying Methane and Methanol Metabolism of “Methylotuvimicrobium buryatense” 5GB1C under Substrate Limitation

mSystems, 2019
Methanotrophic bacteria are a group of prokaryotes capable of using methane as their sole carbon and energy source. Although efforts have been made to simulate and elucidate their metabolism via computational approaches or 13C tracer analysis, major gaps
Lian He, Yanfen Fu, Mary E. Lidstrom
doaj   +3 more sources

Endogenous Nutritive Support after Traumatic Brain Injury: Peripheral Lactate Production for Glucose Supply via Gluconeogenesis. [PDF]

, 2015
We evaluated the hypothesis that nutritive needs of injured brains are supported by large and coordinated increases in lactate shuttling throughout the body.
Brooks, George A, Glenn, Thomas C, Horning, Michael A, Hovda, David A, Johnson, Matthew L, Martin, Neil A, McArthur, David L, Vespa, Paul   +7 more
core   +1 more source

In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases

Advanced Science, EarlyView.
This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du, Zetao Dang, Baofeng Xu, Jiajun Xu, Dan Wang, Yuewei Zhang, Shoujun Zhu   +6 more
wiley   +1 more source

Constraining Genome-Scale Models to Represent the Bow Tie Structure of Metabolism for 13C Metabolic Flux Analysis

Metabolites, 2018
Determination of internal metabolic fluxes is crucial for fundamental and applied biology because they map how carbon and electrons flow through metabolism to enable cell function. 13 C Metabolic Flux Analysis ( 13 C MFA) and Two-Scale
Tyler W. H. Backman, David Ando, Jahnavi Singh, Jay D. Keasling, Héctor García Martín   +4 more
doaj   +1 more source

Bomb-¹⁴C analysis of ecosystem respiration reveals that peatland vegetation facilitates release of old carbon [PDF]

, 2009
The largest terrestrial-to-atmosphere carbon flux is respired CO₂. However, the partitioning of soil and plant sources, understanding of contributory mechanisms, and their response to climate change are uncertain.
A.E. Fallick, A.P. Rowland, Amundson, Billett, Bol, Bol, Bond-Lamberty, Boutton, Briones, Chanton, Chanton, Chanton, Charman, Clymo, Clymo, Clymo, Colmer, Coplen, Craig, Duranceau, Duranceau, Eddy, Ehleringer, Evans, Fontaine, Forrest, Freeman, Fu, Garnett, Gaudinski, Ghashghaie, Ghashghaie, Gorham, Grogan, Hahn, Hardie, Hardie, Harkness, Harrison, Heal, Högberg, Joabsson, Jobbagy, Jungner, Klumpp, Koarashi, Koncalová, Kuzyakov, Lalonde, Levin, M.H. Garnett, Macdonald, Marinier, N.J. Ostle, Ostle, Ostle, Piao, Piao, Price, Proctor, Raskin, Raskin, Reimer, Rinnan, S.M.L. Hardie, Sapronov, Schimel, Schutz, Schuur, Scott, Shannon, Silvola, Silvola, Slota, Strom, Stuiver, Subke, Taylor, Tcherkez, Tipping, Tolonen, Trumbore, Turetsky, Verville, Waldron, Ward, Ward, Watson, Wookey, Xu, Yakir   +90 more
core   +1 more source

Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism

Advanced Science, EarlyView.
Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards, Ella‐May Hards, Sofia N. dos Santos, Hannah E. Greenwood, Madeleine E. George, Andrea Emanuelli, Muhammet Tanc, Thomas R. Eykyn, Timothy H. Witney   +8 more
wiley   +1 more source