Results 101 to 110 of about 35,774 (283)

From Escherichia coli mutant 13C labeling data to a core kinetic model: A kinetic model parameterization pipeline.

PLoS Computational Biology, 2019
Kinetic models of metabolic networks offer the promise of quantitative phenotype prediction. The mechanistic characterization of enzyme catalyzed reactions allows for tracing the effect of perturbations in metabolite concentrations and reaction fluxes in
Charles J Foster, Saratram Gopalakrishnan, Maciek R Antoniewicz, Costas D Maranas   +3 more
doaj   +1 more source

Nutritional importance of benthic bacteria for deep-sea nematodes from the Arctic ice margin: Results of an isotope tracer experiment [PDF]

, 2010
A
Guilini, Katja, Middelburg, Jack J., Soetaert, Karline, Van Oevelen, Dick, Vanreusel, Ann   +4 more
core   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Analysis of metabolic flux using dynamic labeling and metabolic modeling [PDF]

, 2013
Metabolic fluxes and the capacity to modulate them are a crucial component of the ability of the plant cell to react to environmental perturbations. Our ability to quantify them and to attain information concerning the regulatory mechanisms which control
Fernie, A., Morgan, J.
core   +2 more sources

13C-metabolic flux analysis in glycerol-assimilating strains of Saccharomyces cerevisiae.

The Journal of general and applied microbiology, 2021
Glycerol is an attractive raw material for the production of useful chemicals using microbial cells. We previously identified metabolic engineering targets for the improvement of glycerol assimilation ability in Saccharomyces cerevisiae based on adaptive laboratory evolution (ALE) and transcriptome analysis of the evolved cells.
Taiji Yuzawa, Tomokazu Shirai, Ryoko Orishimo, Kazuki Kawai, Akihiko Kondoh, Takashi Hirasawa   +5 more
openaire   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

13 C-MFA helps to identify metabolic bottlenecks for improving malic acid production in Myceliophthora thermophila

Microbial Cell Factories
Background Myceliophthora thermophila has been engineered as a significant cell factory for malic acid production, yet strategies to further enhance production remain unclear and lack rational guidance.
Junfeng Jiang, Defei Liu, Jingen Li, Chaoguang Tian, Yingping Zhuang, Jianye Xia   +5 more
doaj   +1 more source

Experimental flux measurements on a network scale

Frontiers in Plant Science, 2011
Metabolic flux is a fundamental property of living organisms. In recent years, methods for measuring metabolic flux in plants on a network scale have evolved further.
Jörg eSchwender
doaj   +1 more source

Maximizing efficiency of rumen microbial protein production. [PDF]

, 2015
Rumen microbes produce cellular protein inefficiently partly because they do not direct all ATP toward growth. They direct some ATP toward maintenance functions, as long-recognized, but they also direct ATP toward reserve carbohydrate synthesis and ...
Andries, Argyle, Armstead, Asanuma, Asanuma, Atasoglu, Atasoglu, Atasoglu, Bailey, Bailey, Baldwin, Baldwin, Bas, Bond, Bond, Bond, Buurman, Caldara, Chen, Cheng, Clapperton, Clark, Cook, Costerton, Cotta, Cotta, Counotte, Denton, Diaz, Diez-Gonzalez, Dijkstra, Dijkstra, Dijkstra, Duncan, Dunne, Falony, Ferla, Fields, Firkins, Firkins, Firkins, Firkins, Flint, Forsberg, Gaudet, Gottschalk, Hackmann, Hackmann, Hackmann, Hall, Hanigan, Hindson, Hino, Hobson, Hobson, Hottiger, Hristov, Hristov, Isaacson, Janssen, Jenkins, Jouany, Kajikawa, Kajikawa, Kajikawa, Kalcheva, Karnati, Kim, Koenig, Krause, Kristensen, Larsson, Leedle, Lohkamp, Lou, Lou, Lou, Louis, Mackie, Maia, Martin, Matheron, Matulova, McAllan, Morgan, Morgavi, Morrison, Morrison, Mountfort, Mouriño, Mulder, Nagaraja, Neijssel, Newbold, Newsholme, Newsholme, Nouaille, NRC., Oldick, Or-Rashid, Otto, Paillard, Paulus, Pirt, Piwonka, Portais, Prabhu, Preiss, Prins, Rosewarne, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Ryan, Saleem, Schönheit, Shi, Shi, Stewart, Storm, Stouthamer, Suen, Teixeira de Mattos, Tempest, Tempest, Ungerfeld, van Hijum, Van Hoven, Van Kessel, Van Kessel, Van Soest, Van Urk, Vandehaar, Walker, Wallace, Wallace, Wang, Weimer, Weimer, Weimer, Wells, Wells, White, Wilkinson, Williams, Williams, Yang, Ze, Zhou   +158 more
core   +2 more sources

Metabolic compartmentation in 13C metabolic flux analysis of Chinese hamster ovary cells

, 2023
Chinese hamster ovary cells is currently a prime focus in mAb production, comprising over 70% of the total approved biologics. The coming patent expiration of blockbuster drugs triggers new market competition for alternative biosimilars. These alternatives create price competition, hence, biosimilar development has been driven by the need to reduce the
openaire   +3 more sources