Results 121 to 130 of about 35,774 (283)

FluxSimulator: An R Package to Simulate Isotopomer Distributions in Metabolic Networks [PDF]

The representation of biochemical knowledge in terms of fluxes (transformation rates) in a metabolic network is often a crucial step in the development of new drugs and efficient bioreactors.
Ivo H. M. van Stokkum, Jaap Heringa, Johannes H. G. M. van Beek, Katharine M. Mullen, Thomas W. Binsl   +4 more
core   +1 more source

A Cascade Recognition of Activatable Probe for Fluorescence Navigation Glioblastoma Surgery: Overcoming Blood‐Brain Barrier and Off‐Target Limitations

Advanced Science, EarlyView.
A cascade recognition of activatable probe ANG‐hCy‐MC is used for high‐precision depiction of glioblastoma (GBM) margin. This probe crosses the blood‐brain barrier (BBB) through LRP1 receptor‐mediated transport and provides excellent fluorescence signal contrast between the tumor and normal tissues, thereby enabling ultra‐selective imaging and precise ...
Xinru An, Yu Guo, Yongning Bian, Yanli Tan, Chuan Fang, Hengzhu Zhang, Xueqian Chen, Lin Yuan, Dongdong Su   +8 more
wiley   +1 more source

Improved 13C metabolic flux analysis in Escherichia coli metabolism: application of a high-resolution MS (GC-EI-QTOF) for comprehensive assessment of MS/MS fragments. [PDF]

J Ind Microbiol Biotechnol, 2023
Richter C, Grafahrend-Belau E, Ziegler J, Raorane ML, Junker BH.   +4 more
europepmc   +1 more source

Self‐Assembled Myricetin‐Arginine Conjugate Nanozymes for Targeted Suppression of Joint Inflammation and Osteoclastogenesis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Carrier‐free myricetin‐arginine conjugate nanozymes (MANZs) have been fabricated through a Mannich reaction and spontaneous self‐assembly. MANZs selectively accumulate in inflamed joints by targeting M1 macrophages via CAT2‐mediated uptake. The nanozymes can effectively modulate macrophage polarization, suppress osteoclast differentiation, and mitigate
Jiachang Hong, Penghao Ji, Jinxi An, Junchao Huang, Ziheng Bu, Xudong Zhang, Wei Liu, Tingyu Wu, Sen Wang, Wei Zhu, Yuhui Li, Jixian Wan, Sudan Xu, Minfeng Huo, Peng Wu   +14 more
wiley   +1 more source

Sugar‐Armored Pesticides: Self‐Assembled System for Enhanced Foliar Adhesion and Sustained Delivery of Hydrophobic Antimicrobials Against Bacterial Diseases

Advanced Science, EarlyView.
This study develops a sugar‐armored, self‐assembled pesticide delivery system that enhances foliar adhesion, provides sustained release, effectively disrupts biofilms, and demonstrates superior bactericidal activity for improved disease control.
Jinghan Yang, Juan Liu, Xiaohui Wang, Peiyi Wang   +3 more
wiley   +1 more source

Intracellular Fate of Universally Labelled 13C Isotopic Tracers of Glucose and Xylose in Central Metabolic Pathways of Xanthomonas oryzae

Metabolites, 2018
The goal of this study is to map the metabolic pathways of poorly understood bacterial phytopathogen, Xanthomonas oryzae (Xoo) BXO43 fed with plant mimicking media XOM2 containing glutamate, methionine and either 40% [13C5] xylose or 40% [13C6] glucose ...
Manu Shree, Shyam K. Masakapalli
doaj   +1 more source

Bayesian ¹³C-Metabolic Flux Analysis of Parallel Tracer Experiments in Granulocytes: A Directional Shift within the Non-Oxidative Pentose Phosphate Pathway Supports Phagocytosis. [PDF]

Metabolites, 2023
Hogg M, Wolfschmitt EM, Wachter U, Zink F, Radermacher P, Vogt JA.   +5 more
europepmc   +1 more source

Dispensability of Escherichia coli's latent pathways

, 2011
Gene-knockout experiments on single-cell organisms have established that expression of a substantial fraction of genes is not needed for optimal growth.
A. E. Motter, Baba, Barab  si, Becker, Blank, Braunstein, Covert, Deluna, Deutscher, Edwards, Emmerling, Feist, Feist, Ferguson, Flores, Fong, Fong, Freilich, Gerdes, Giaever, Goyal, Gu, Hasona, Herring, Hillenmeyer, Hopkins, Hua, Ibarra, Ito, J. S. Lee, Kaufman, Klipp, Kupiec, Mahadevan, Motter, Motter, Nishikawa, Papp, Reed, Reed, S. P. Cornelius, Shi, Smith, Stern, Vinopal, Wagner   +45 more
core   +2 more sources

Time‐Dependent Recovery of Gastric Emptying After Gastrectomy: A 12‐Month Longitudinal Study Using a 13C‐Acetate Breath Test With a Semi‐Solid Meal

Annals of Gastroenterological Surgery, EarlyView.
This study examined time‐dependent changes in gastric emptying after gastrectomy for gastric cancer using a 13C‐acetate breath test with a semi‐solid meal in 95 patients, revealing that gastric emptying was initially delayed at 1 month but significantly accelerated by 12 months postoperatively.
Sachiko Kaida, Katsushi Takebayashi, Mika Kurihara, Reiko Otake, Haruki Mori, Hiromitsu Maehira, Toru Miyake, Shigeki Bamba, Masaji Tani   +8 more
wiley   +1 more source

Bacterial Metabolism During Biofilm Growth Investigated by 13C Tracing

Frontiers in Microbiology, 2018
This study investigated the metabolism of Pseudomonas aeruginosa PAO1 during its biofilm development via microscopy imaging, gene expression analysis, and 13C-labeling. First, dynamic labeling was employed to investigate glucose utilization rate in fresh
Ni Wan, Hao Wang, Chun Kiat Ng, Chun Kiat Ng, Manisha Mukherjee, Manisha Mukherjee, Dacheng Ren, Dacheng Ren, Bin Cao, Bin Cao, Yinjie J. Tang   +10 more
doaj   +1 more source