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Assessment and Expansion of Models for 13C-Metabolic Flux Analysis (MFA) In Vivo
Diabetes, 2018Isotope-based MFA is a valuable tool to determine rates of biochemical reactions in vivo, which cannot be assessed by other approaches. Its application in biomedicine may help to uncover metabolic disease determinants in diabetes and obesity. However, various simplifying assumptions have been applied to constrain models used for in vivo MFA studies ...
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13C metabolic flux analysis of recombinant expression hosts
Current Opinion in Biotechnology, 2014Identifying host cell metabolic phenotypes that promote high recombinant protein titer is a major goal of the biotech industry. (13)C metabolic flux analysis (MFA) provides a rigorous approach to quantify these metabolic phenotypes by applying isotope tracers to map the flow of carbon through intracellular metabolic pathways.
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Assessment of in vitro cardiotoxicity using metabolomics and 13C metabolic flux analysis
2012The potential of respiration measurements, metabolomics and 13C metabolic flux analysis (13CMFA) for the determination of drug-induced cardiotoxicity was analysed. Two cardiac in vitro models, namely murine HL-1 cells and human embryonic stem cell derived cardiomyocytes (hESC-CM) were applied for this purpose. Respiration measurement in HL-1 cells upon
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Topological Wannier cycles induced by sub-unit-cell artificial gauge flux in a sonic crystal
Nature Materials, 2022Ying Wu, Feng Li, Jian-Hua Jiang
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