Results 181 to 190 of about 320,692 (287)

A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis

Advanced Science, EarlyView.
This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang, Miaoyu Li, Tiantian Li, Xiaojie Zang, Haiyang Shi, Yaru Liu, Chengcheng Zhang, Jianxin Zhao, Qixiao Zhai, Wei Chen, Fengwei Tian   +10 more
wiley   +1 more source

Batten disease protein CLN8 enables a non-canonical phospholipid synthesis pathway. [PDF]

Nat Cell Biol
Breithofer J, Fawzy N, Zitta C, Tischitz M, Bulfon D, Hofmann C, Hartig L, Wagner C, Grabner GF, Pirchheim A, Lass A, Taschler U, Turner K, Petkevicius K, Stelzl U, Kratky D, Breinbauer R, Zimmermann R.   +17 more
europepmc   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Condition-Controlled Divergent Reactivity of Nitroaldol Isatin Adducts with Phenols: Friedel-Crafts Alkylation, Skeletal Rearrangement, and Spirocyclic Oxime Formation. [PDF]

Int J Mol Sci
Arutiunov NA, Shtal DA, Tolstov KV, Korneeva AA, Petrova OV, Zatsepilina AM, Aksenov NA, Ovcharov SN, Aksenov AV.   +8 more
europepmc   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Trinor-Guaiane-Type Sesquiterpenes with Unusual Skeletons from the Okinawan Soft Coral <i>Clavularia viridis</i>. [PDF]

ACS Omega
Tani K, Nagasaka M, Tsuruta T, Fukushige A, Hojo A, Doe M, Miyake H, Morimoto Y, Hashimoto M, Marumoto S, Ito M, Kumagai M, Nishikawa K, Ishii T.   +13 more
europepmc   +1 more source

Re‐Thinking Electronic Circuit Design Through Emerging Reconfigurable Field Effect Transistors

Advanced Science, EarlyView.
Graphical illustration of reconfigurable field effect transistor (RFET) operation modes, including n‐type, p‐type, and ambipolar transport, as well as their areas of application discussed in this review: digital circuit design, analog circuit design, post‐Shannon computing, and sensing. ABSTRACT Reconfigurable field‐effect transistors, short RFETs, are
Jens Trommer, Juan P. Martinez, Yuxuan He, Giulio Galderisi, Katrin Pingen, Eduardo Sergio Oliveros‐Mata, Lisa Tellis, Cigdem Cakirlar, Christoph Beyer, Brojogopal Sapui, Joachim Knoch, Klaus Hofmann, Sandro Carrara, Eugenio Cantatore, Max C. Lemme, Ian O'Connor, Akash Kumar, Andre Heinzig, Thomas Mikolajick, Walter M. Weber   +19 more
wiley   +1 more source

¹H, ¹³C, and ¹⁵N backbone resonance assignment of the N-terminal 280 amino acids of human NHERF1 protein. [PDF]

Biomol NMR Assign
Hornero-Romera A, Treviño MÁ, Pantoja-Uceda D, Millán J, Jiménez MÁ.   +4 more
europepmc   +1 more source