Results 161 to 170 of about 320,692 (287)

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Differential activation of TCA cycle activity and PDH flux by dichloroacetate in skeletal muscle measured by hyperpolarized [2-¹³C,3-²H₃]pyruvate. [PDF]

iScience
Lin SH, Cho A, Huynh MT, Erfani Z, Kucejova B, Dewage SW, Jue T, Fu X, Kovács Z, Burgess SC, Park JM.   +10 more
europepmc   +1 more source

Functional MXene Inks for Printed Electronics: Chemistry, Rheology, and Devices

Advanced Science, EarlyView.
Functional MXene inks are emerging as building blocks for MXetronics, connecting MXene synthesis, surface functionalization, ink formulation, and advanced printing with device‐level applications. This review maps how composition, stability, rheology, and processability govern printed structures and enable high‐performance sensors, energy‐storage ...
Shahzaib Ali, Faisal Shahzad, Hamza Hussain, Muhammad Abbas, Dae‐Hyun Cho, Doyoung Byun, Hassan A. Arafat   +6 more
wiley   +1 more source

Quantitation of PEMT and Kennedy Pathways in Liver Phosphatidylcholine Biosynthesis Using NMR. [PDF]

Anal Chem
Lee JY, Manh Nguyen TT, Nguyen TH, Cho E, Lee S, Kwon HN, Jeong LS, Jarhad DB, Cha JW, Park S.   +9 more
europepmc   +1 more source

An Injectable and Self‐Reinforced Piezoelectric Hydrogel for Irregular Bone Defects Regeneration: Dynamic Epigenetic Regulation Approach

Advanced Science, EarlyView.
An injectable and self‐reinforcing RSF‐based piezoelectric hydrogel conforms to irregular bone defects and progressively strengthens in situ, overcoming the trade‐off between injectability and mechanical stability. Mechanical loading generates bioelectrical cues that promote P300‐mediated H3K9 acetylation and upregulate PTH1R expression, thereby ...
Yu‐Kai Huang, Juan Li, Miao‐Miao Yang, Chao Jia, Quan‐Xin Gong, Guang‐Cheng Yuan, Dong Zhou, Wen‐Hui Shen, Zeng‐Gan Chen, Zhi‐Rui Dong, Jin‐Wang Huang, Jie Peng, Di‐Han Su, Ming‐Dong Zhao, Jian Dong, Li‐Bo Jiang   +15 more
wiley   +1 more source

Sequence Inversion Dictates the Antiproliferative Activity of Bidirectional Tryptophan-Containing Dipeptide Libraries. [PDF]

J Pept Sci
Díaz JB, Khan AN, González-Bakker A, Padrón JM.   +3 more
europepmc   +1 more source

Bioelectrochemically Powered Out‐of‐Equilibrium Hydrogels Enable Feedback‐Regulated Functions

Advanced Science, EarlyView.
A bioelectrochemically powered hydrogel operates far from equilibrium via an antagonistic redox cycle that regulates disulfide exchange within a polyrotaxane network. Coupling electrochemical mediator cycling with enzymatic feedback enables dynamic control of hydrogel mechanics and transport properties, driving glucose‐responsive insulin release with ...
Roberto Baretta, Marco Frasconi
wiley   +1 more source

Integrated Solid/Solution NMR Assignment Enables Mapping of Dynamics and Ligand Binding in a 134 kDa Enzyme. [PDF]

J Am Chem Soc
Napoli F, Singh R, Kapitonova A, Aitenbichler V, Toscano G, Perrone B, Schanda P.   +6 more
europepmc   +1 more source

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

Advanced Science, EarlyView.
A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian, Jiasha Wu, Fusheng Xu, Yan Zuo, Huaxing Shen, Rui Ji, Luyi Wang, Na Li, Yanting Sun, Yongsheng Yu, Yejiao Shi, Honggang Hu, Feng Xu, Dan Huang, Xiaochun Hu   +14 more
wiley   +1 more source

Laboratory Synthesis, Characterization, and Py-GCMS-Based 13C Quantification of 13C‑Enriched Polyethylene

ACS Omega
Ravindra Reddy Chowreddy, Alireza Hassani, Gustav Vaaje-Kolstad, Bavan Mylvaganam   +3 more
doaj   +1 more source