Results 91 to 100 of about 35,777 (291)
Advanced Science, EarlyView.Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun +14 more
wiley +1 more source
Frontiers in Plant Science, 2014 The use of large-scale or genome-scale metabolic reconstructions for modeling and simulation of plant metabolism and integration of those models with large-scale omics and experimental flux data is becoming increasingly important in plant metabolic ...
Jordan eHay +5 more
doaj +1 more source
Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging
Advanced Science, EarlyView.Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika +22 more
wiley +1 more source
Analysis of metabolic flux using dynamic labeling and metabolic modeling [PDF]
, 2013 Metabolic fluxes and the capacity to modulate them are a crucial component of the ability of the plant cell to react to environmental perturbations. Our ability to quantify them and to attain information concerning the regulatory mechanisms which control
Fernie, A., Morgan, J.
core +2 more sources
Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy
Advanced Science, EarlyView.Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro +6 more
wiley +1 more source
mSystems, 2019 Methanotrophic bacteria are a group of prokaryotes capable of using methane as their sole carbon and energy source. Although efforts have been made to simulate and elucidate their metabolism via computational approaches or 13C tracer analysis, major gaps
Lian He, Yanfen Fu, Mary E. Lidstrom
doaj +3 more sources
Metabolic compartmentation in 13C metabolic flux analysis of Chinese hamster ovary cells
, 2023 Chinese hamster ovary cells is currently a prime focus in mAb production, comprising over 70% of the total approved biologics. The coming patent expiration of blockbuster drugs triggers new market competition for alternative biosimilars. These alternatives create price competition, hence, biosimilar development has been driven by the need to reduce the
openaire +3 more sources
In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases
Advanced Science, EarlyView.This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du +6 more
wiley +1 more source
Metabolites, 2018 Determination of internal metabolic fluxes is crucial for fundamental and applied biology because they map how carbon and electrons flow through metabolism to enable cell function. 13 C Metabolic Flux Analysis ( 13 C MFA) and Two-Scale
Tyler W. H. Backman +4 more
doaj +1 more source
Endogenous Nutritive Support after Traumatic Brain Injury: Peripheral Lactate Production for Glucose Supply via Gluconeogenesis. [PDF]
, 2015 We evaluated the hypothesis that nutritive needs of injured brains are supported by large and coordinated increases in lactate shuttling throughout the body.
Brooks, George A +7 more
core +1 more source