Results 101 to 110 of about 35,777 (291)

Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism

Advanced Science, EarlyView.
Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards, Ella‐May Hards, Sofia N. dos Santos, Hannah E. Greenwood, Madeleine E. George, Andrea Emanuelli, Muhammet Tanc, Thomas R. Eykyn, Timothy H. Witney   +8 more
wiley   +1 more source

From Escherichia coli mutant 13C labeling data to a core kinetic model: A kinetic model parameterization pipeline.

PLoS Computational Biology, 2019
Kinetic models of metabolic networks offer the promise of quantitative phenotype prediction. The mechanistic characterization of enzyme catalyzed reactions allows for tracing the effect of perturbations in metabolite concentrations and reaction fluxes in
Charles J Foster, Saratram Gopalakrishnan, Maciek R Antoniewicz, Costas D Maranas   +3 more
doaj   +1 more source

Bomb-¹⁴C analysis of ecosystem respiration reveals that peatland vegetation facilitates release of old carbon [PDF]

, 2009
The largest terrestrial-to-atmosphere carbon flux is respired CO₂. However, the partitioning of soil and plant sources, understanding of contributory mechanisms, and their response to climate change are uncertain.
A.E. Fallick, A.P. Rowland, Amundson, Billett, Bol, Bol, Bond-Lamberty, Boutton, Briones, Chanton, Chanton, Chanton, Charman, Clymo, Clymo, Clymo, Colmer, Coplen, Craig, Duranceau, Duranceau, Eddy, Ehleringer, Evans, Fontaine, Forrest, Freeman, Fu, Garnett, Gaudinski, Ghashghaie, Ghashghaie, Gorham, Grogan, Hahn, Hardie, Hardie, Harkness, Harrison, Heal, Högberg, Joabsson, Jobbagy, Jungner, Klumpp, Koarashi, Koncalová, Kuzyakov, Lalonde, Levin, M.H. Garnett, Macdonald, Marinier, N.J. Ostle, Ostle, Ostle, Piao, Piao, Price, Proctor, Raskin, Raskin, Reimer, Rinnan, S.M.L. Hardie, Sapronov, Schimel, Schutz, Schuur, Scott, Shannon, Silvola, Silvola, Slota, Strom, Stuiver, Subke, Taylor, Tcherkez, Tipping, Tolonen, Trumbore, Turetsky, Verville, Waldron, Ward, Ward, Watson, Wookey, Xu, Yakir   +90 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine [PDF]

, 2012
Background: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism.
Barduhn, Tobias, Heinzle, Elmar, Peifer, Susanne, Schneider, Konstantin, Volmer, Dietrich A., Zimmet, Sarah   +5 more
core   +1 more source

Metabolic fluxes in recombinant Streptomyces lividans analyzed with 13 C-based metabolic flux analysis

IFAC-PapersOnLine, 2016
Abstract: Streptomyces lividans is an interesting host for the production of heterologous proteins. Expression of these foreign proteins often results in a metabolic burden leading to unsatisfactory yields. In this work, metabolic fluxes in Streptomyces lividans producing thermostable cellulase A are quantified.
Jeroen Bouvin, Wouter Daniels, Jozef Anné, Bart Nicolaï, Kristel Bernaerts   +4 more
openaire   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

13 C-MFA helps to identify metabolic bottlenecks for improving malic acid production in Myceliophthora thermophila

Microbial Cell Factories
Background Myceliophthora thermophila has been engineered as a significant cell factory for malic acid production, yet strategies to further enhance production remain unclear and lack rational guidance.
Junfeng Jiang, Defei Liu, Jingen Li, Chaoguang Tian, Yingping Zhuang, Jianye Xia   +5 more
doaj   +1 more source

Experimental flux measurements on a network scale

Frontiers in Plant Science, 2011
Metabolic flux is a fundamental property of living organisms. In recent years, methods for measuring metabolic flux in plants on a network scale have evolved further.
Jörg eSchwender
doaj   +1 more source

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

Advanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma, Yunxuan Liu, Huijuan Zhang, Yian Fang, Yizhe Xue, Junsheng Xue, Ziqiong Jiang, Tianyan Zhou, Yanyun Hao, Fei Xie, Lei Miao   +10 more
wiley   +1 more source