Results 111 to 120 of about 35,777 (291)

Molecular‐Scale Tuning of Low‐Molecular‐Weight Gelators Controls Supramolecular Assembly and Directs Human Mesenchymal Stem Cell Growth

Angewandte Chemie, EarlyView.
Chemistry in charge of biology! Simple low‐molecular‐weight gelators, with minor modifications in molecular structure, self‐assemble differently and can also co‐assemble when simultaneously triggered. This creates a family of gels with different properties that direct the growth of stem cells in different ways.
Chayanan Tangsombun, Amy Simpson, Rebecca L. Charlton, Lucy E. Sabin, Paul G. Genever, David K. Smith   +5 more
wiley   +2 more sources

Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli

Molecular Systems Biology, 2007
To which extent can optimality principles describe the operation of metabolic networks? By explicitly considering experimental errors and in silico alternate optima in flux balance analysis, we systematically evaluate the capacity of 11 objective ...
Robert Schuetz, Lars Kuepfer, Uwe Sauer
doaj   +1 more source

Flux-balance modelling of plant metabolism

Frontiers in Plant Science, 2011
Flux-balance modelling of plant metabolic networks provides an important complement to 13C-based metabolic flux analysis. Flux-balance modelling is a constraints-based approach in which steady-state fluxes in a metabolic network are predicted by using ...
Lee James Sweetlove, R. George eRatcliffe   +1 more
doaj   +1 more source

Nutritional importance of benthic bacteria for deep-sea nematodes from the Arctic ice margin: Results of an isotope tracer experiment [PDF]

, 2010
A
Guilini, Katja, Middelburg, Jack J., Soetaert, Karline, Van Oevelen, Dick, Vanreusel, Ann   +4 more
core   +2 more sources

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Análisis cuantitativo y modelización del metabolismo de la levadura Pichia pastoris [PDF]

, 2008
Consultable des del TDXTítol obtingut de la portada digitalitzadaEl presente trabajo está centrado en el análisis y modelización del metabolismo central de la levadura Pichia pastoris.
Santos de Jesus, Sérgio
core   +3 more sources

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Nitrogen‐Boosted H2O2 Production of Arginine‐Polyphenol Nanozyme Drives Oxidative Eustress for Hair Regeneration

Advanced Science, EarlyView.
PEA nanoenzymes are assembled from L‐arginine and EGCG. The nitrogen element in arginine enhances the thermodynamic feasibility of H2O2 production through PEA's oxygen reduction catalysis, enabling nitrogen‐dependent H2O2 release. Intradermal delivery of PEA via microneedles promotes efficient H2O2 synthesis, thereby stimulating regrowth in telogen ...
Yifei Wang, Yaojia Yang, Aoxue Wang, Chen Shen, Shenliang Tan, Changsheng Liu, Yuzheng Zhao, Xue Qu   +7 more
wiley   +1 more source

Application of 13C flux analysis for diagnosis of metabolic disorders

, 2020
{"references": ["Anke P Willems et al. 2019. Biochimica et Biophysica Acta (BBA) - General Subjects. Vol 1863, 1471-1479"]}
Noga, Marek J, Conte, Federica, Veizaj, Raisa, Wintjes, Liesbeth, Kwast, Hanneke, van den Brandt, Frans C, Rodenburg, Richard J, Lefeber, Dirk J   +7 more
openaire   +1 more source

Bioorthogonal Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC) for Precise Targeted Protein Degradation

Advanced Science, EarlyView.
Bioorthogonal SDPTAC harnesses US‐responsive Ce6‐TCO and Tz ligands via IEDDA click chemistry to assemble degraders in situ, generating ROS that selectively eliminate nuclear, cytosolic, and membrane proteins, thereby suppressing deep‐seated tumors in vivo.
Yuhan Bao, Yaojin Zhu, Xinhao Wei, Yuxin Fang, Jiayi Zhu, Fei Gao, Guoqiang Dong, Shipeng He, Chunquan Sheng   +8 more
wiley   +1 more source