Results 71 to 80 of about 35,777 (291)
Advanced Healthcare Materials, EarlyView.Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales +11 more
wiley +1 more source
Flux-P: Automating Metabolic Flux Analysis
Metabolites, 2012 Quantitative knowledge of intracellular fluxes in metabolic networks is invaluable for inferring metabolic system behavior and the design principles of biological systems.
Birgitta E. Ebert +3 more
doaj +1 more source
Metabolite concentrations, fluxes and free energies imply efficient enzyme usage. [PDF]
, 2016 In metabolism, available free energy is limited and must be divided across pathway steps to maintain a negative ΔG throughout. For each reaction, ΔG is log proportional both to a concentration ratio (reaction quotient to equilibrium constant) and to a ...
Amador-Noguez, Daniel +6 more
core +2 more sources
Advanced Materials, EarlyView.The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li +19 more
wiley +1 more source
FluxPyt: a Python-based free and open-source software for 13C-metabolic flux analyses [PDF]
PeerJ, 2018 13C-Metabolic flux analysis (MFA) is a powerful approach to estimate intracellular reaction rates which could be used in strain analysis and design.
Trunil S. Desai, Shireesh Srivastava
doaj +2 more sources
What do cells actually want? [PDF]
, 2016 Genome-scale models require an objective function representing what an organism strives for. A method has been developed to infer this fundamental biological function from data.Please see related Research article: www.dx.doi.org/10.1186/s13059-016-0968 ...
Feist, Adam M, Palsson, Bernhard O
core +3 more sources
Metabolism of the fast-growing bacterium Vibrio natriegens elucidated by 13C metabolic flux analysis [PDF]
Metabolic Engineering, 2017 Vibrio natriegens is a fast-growing, non-pathogenic bacterium that is being considered as the next-generation workhorse for the biotechnology industry. However, little is known about the metabolism of this organism which is limiting our ability to apply rational metabolic engineering strategies.
Christopher P, Long +3 more
openaire +2 more sources
Advanced Materials Technologies, EarlyView.This critical review presents a comprehensive roadmap for the precision 3D printing of cellulose. Quantitative correlations link ink formulation and rheological properties to print fidelity and final material performance. This framework guides the development of advanced functional materials, from biomedical scaffolds to electromagnetic shielding ...
Majed Amini +3 more
wiley +1 more source
The short-chain fatty acid uptake fluxes by mice on a guar gum supplemented diet associate with amelioration of major biomarkers of the metabolic syndrome [PDF]
, 2014 Studies with dietary supplementation of various types of fibers have shown beneficial effects on symptoms of the metabolic syndrome. Short-chain fatty acids (SCFAs), the main products of intestinal bacterial fermentation of dietary fiber, have been ...
Bakker, Barbara M +8 more
core +5 more sources
Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages
Advanced Science, EarlyView.Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu +14 more
wiley +1 more source