Results 171 to 180 of about 7,153,567 (281)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Desbordamientos culturales en torno al 15-M

Revista Teknokultura, 2013
Este artículo es una exploración del contexto cultural amplio del movimiento 15-M en el estado español. Comienza por proponer que el 15-M es un síntoma más de un generalizado desgaste de la hegemónica “Cultura de la transición”, que estableció una serie de acuerdos tácitos en torno a la necesidad de una sociedad vertical y de expertos basada en el ...
openaire   +2 more sources

Prenylated acylphloroglucinols from the fruits of Hypericum patulum. [PDF]

Nat Prod Bioprospect
Qiu YF, Zhou Y, Chen C, Huang J, Yang XW.   +4 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

“The 15-M movement: Formed by and Formative of Counter-mapping and Spatial Activism” by Stephen Luis Vilaseca [PDF]

, 2014
Afinoguénova, Eugenia
core   +1 more source

ATTAC como parte del movimiento 15 M

, 2011
No se trata por tanto de oponer individuo y comunidad, sino de encontrar la forma de organización social que maximice la libertad de todos los ciudadanos, respetando su diversidad. Se trata de estar juntos, influenciándonos como iguales, respetando la singularidad de cada uno.
openaire   +1 more source

A Taxonomic Revision of the Dichotomius depressicollis (Harold, 1867) Species Group (Coleoptera: Scarabaeidae: Scarabaeinae), with Description of Five New Species. [PDF]

Neotrop Entomol
Arias-Buriticá JA, Vaz-de-Mello FZ.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Predominance of antimicrobial resistance genes and high-risk clones among Gram negatives from clinical sources in Accra-Ghana. [PDF]

PLoS One
Boateng W, Owusu-Nyantakyi C, Owusu F, Amuasi GR, Mohktar Q, Nilsson P, Adu B, Hendriksen RS, Egyir B.   +8 more
europepmc   +1 more source