Results 171 to 180 of about 34,484,154 (281)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Functional and Fertility Outcomes of Two Milk-Based Extenders for Short-Term Storage of Ram Semen at 15°C. [PDF]

Reprod Domest Anim
Neila-Montero M, Iniesta-Cuerda M, Hernández-Serrano J, Díaz-Hernández E, Vidal-Garcia C, Laborda-Gomariz JÁ, Serrallé M, Gallego R, García-García Ó, Garde JJ, Soler AJ.   +10 more
europepmc   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Drimane-Pyrone-Type Meroterpenoids and Co-Isolated Compounds from the Deep-Sea Fungus <i>Penicillium rubens</i> MABC05 and Their Anti-Ferroptotic and Cytotoxic Activities. [PDF]

Mar Drugs
Liu L, Yang X, Hu C, Wang P, Luo Z, Lv Q, Zhang Y, Cheng Z.   +7 more
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Interferon-γ-response to mycobacterial glycopeptidolipids in patients with pulmonary non-tuberculous mycobacterial infection. [PDF]

Med Microbiol Immunol
Steindor M, Dachmann S, Stehling F, Olivier M, Kehrmann J, Horn PA, Villar-Hernández R, Straßburg S, Welsner M, Sutharsan S, Lindemann M.   +10 more
europepmc   +1 more source

Causas y antecedentes del 15-M.

El liberalismo, la socialdemocracia y el comunismo proyectaban los conflictos del presente en el futuro, imaginando la solución, indica el autor. Pero ese esquema ya no funciona en el siglo XXI. El 15M fue la primera expresión de ese presente sin futuro. Jorge Lago, sociólogo, y Profesor en la Universidad Carlos III de Madrid.
openaire   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source