Results 151 to 160 of about 7,153,567 (281)
, 2018 En una democracia representativa la campaña electoral es la antesala del voto. El valor del sufragio depende del debate público que le precede. Una campaña abierta, plural y competitiva garantiza el voto libre y soberano. En las Elecciones Generales de 2004 y en las elecciones locales y autonómicas de 2011, los actos electorales fueron desplazados por ...
F. Sampedro Blanco, Víctor +1 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
15-M and the digital fifth-column
Revista Teknokultura, 2011 Social movements around May 15th have changed the political landscape. The use of some features such as networking, pacifism, transversality, represents a challenge for official politicians. Public space has been retaken and an impressive work has been generated without leaders.
Andoni Alonso, Iñaki Arzoz
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Madrid 15-M: lo poético político
, 2014 Guillermo G. Peydró, en su escrito “Madrid, 15-M: lo poético político” nos interpela a través de una pregunta coyuntural: ¿en qué medida puede lo poético ser político, evitar la esterilización inevitable del negocio del arte contemporáneo, provocar algún cambio real?
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Repercusiones mediáticas del movimiento social 15-M [PDF]
, 2012 Díaz Testa, Tatiana
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15-M: INTENTOS DE APROXIMAR ÉTICA, POLÍTICA Y DEMOCRACIA
Oxímora. Revista Internacional de Ética y Política, 2013 En el 15-M confluyeron un conjunto heterogéneo de personas y grupos que dieron apoyo a lo que acabaría siendo una especie de plataforma o espacio de movilización que recogía distintas reivindicaciones, unas de carácter económico y social, y otras de naturaleza política.
Mir Garcia, Jordi, Prat Carvajal, Enric
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source