COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Targeting Cancer Cachexia: A Mechanistic Evaluation of Anti-GDF-15 Antibody-Based Combination Therapies. [PDF]
J Cachexia Sarcopenia MuscleBreen DM +14 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Emergence of ST383 carbapenem-resistant <i>Klebsiella pneumoniae</i> harbouring <i>bla</i> <sub>NDM-5</sub> and <i>bla</i> <sub>OXA-48</sub> carbapenemase genes in a Romanian tertiary-care hospital. [PDF]
JAC Antimicrob ResistGheorghiță V +11 more
europepmc +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Agustín García Calvo in the 15-M Movement
, 2016 Este artículo se adentra en el pensamiento de un autor que no ha sido estudiado. Además, entiende que la mejor manera de iniciar su estudio es la Asamblea libre de la Puerta del Sol de Madrid en el 15-M. La posición de García Calvo no fue influyente en este movimiento, pero puede ayudar a comprenderlo: en su origen, en su desarrollo posterior e incluso
openaire +1 more source
A Combined MS/MS and IMS Study Into the Fragmentation Pathway of Nifedipine. [PDF]
J Mass SpectromHan P, Thomassen N, Honing M.
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Patient-reported and caregiver-reported outcomes after limb salvage or amputation for pediatric bone and soft tissue sarcomas: a scoping review. [PDF]
Support Care CancerJibb L +7 more
europepmc +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source