Results 101 to 110 of about 14,106,984 (307)

Tuning of CHO secretional machinery improve activity of secreted therapeutic sulfatase 150-fold

, 2023
Niklas Thalén, Mona Moradi Barzadd, Magnus Lundqvist, Johanna Rodhe, Monica Andersson, Gholamreza Bidkhori, Dominik Possner, Chao Su, Joakim Nilsson, Peter Eisenhut, Magdalena Malm, Alice Karlsson, Jeanette Vestin, Johan Forsberg, Erik Nordling, Adil Mardinoğlu, Anna-Luisa Volk, Anna Sandegren, Johan Rockberg   +18 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Towards examiner-independent reproducible abdominal ultrasound examinations

Current Directions in Biomedical Engineering
The proposed system aims at reproducibility in ultrasound follow-up examinations by storing the position of the ultrasound transducer in relation to acquired images. The system utilizes an electromagnetic tracking system.
Baader Tobias, Nam Bach Thanh, Yavuz Sümeyra, Brand Lukas Klaus, Güler Beyda, Grupp Peter, Malek Nisar Peter, Hoffmann Tatjana, Pauluschke-Fröhlich Jan, Fröhlich Eckhart, Burgert Oliver   +10 more
doaj   +1 more source

Robustness and generalisation study of a new regression-based neural network method for capacitors in power electronics

e-Prime: Advances in Electrical Engineering, Electronics and Energy
The growing prevalence of modular multilevel converters (MMC) in various electrical engineering applications necessitates effective strategies for ensuring the robustness and reliability of key components such as capacitors.
Christian Vorobev, Daniel Vahle, Volker Staudt   +2 more
doaj   +1 more source

Institutional Compliance by Firms in Transition Economies [PDF]

This research revisits the effects of a country’s institutional framework on individual firms’ behavior, in particular focusing on their propensity to comply with legal rules in transition economies.
Jorge Guillen, Paola Vargas
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Surface air temperature and its changes over the past 150 years [PDF]

, 1999
P. D. Jones, Mark New, D. E. Parker, Seelye Martin, Ignatius Rigor   +4 more
openalex   +1 more source

Managing your executive MBA program to its maximum sales potential: an exploratory and holistic approach [PDF]

The purpose of this research is to determine methods in which Business Schools can manage its Executive MBA Program in order to achieve maximum desired sales (i.e. enrollment).
Francis PETIT
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source