Results 141 to 150 of about 149,608 (284)

Stable Isotope Analysis as a Tool to Prevent Illicit Wildlife Trade of Songbirds in Brazil

Animal Conservation, EarlyView.
Feather isotopes provide clear differences between wild and captive songbirds in Brazil. Combining multiple isotopes improved classification accuracy and revealed individuals falsely declared as captive‐bred. These results demonstrate the potential of isotope analysis to detect wildlife laundering in the bird trade.
Luiza Brasileiro, Fábio J. V. Costa, Paulo R. R. Ramos, Vladimir E. Costa, Gabriela B. Nardoto   +4 more
wiley   +1 more source

Wet Season Carbon (δ13C) and Nitrogen (δ15N) Composition of Modern Plants as Isotopic Framework for Agropastoral and Palaeoecological Studies in Northern Greece

Archaeometry, EarlyView.
ABSTRACT Mediterranean wetlands are one of Europe's most vital and endangered biodiversity hotspots. This study determined the carbon (δ13C) and nitrogen (δ15N) isotope values of modern plants to construct an isotopic framework by which to contextualize agropastoral management in and around past wetland ecosystems.
Doris Vidas‐Cardador, Amy Styring, Michael Charles, Valasia Isaakidou, Paul Halstead, Amy Bogaard   +5 more
wiley   +1 more source

Fecal Steroids as Tracers of Human Population and Waste Management Practices at the Ancient Maya City of Ucanal, Guatemala

Archaeometry, EarlyView.
ABSTRACT Geochemical data compiled from dried sediments from three water reservoirs at the ancient Maya city of Ucanal, Petén, Guatemala, reveal low to undetectable fecal biomarker concentrations. These low concentrations may be the result of the aerobic decay of sterols combined with well‐managed waste disposal practices.
Jean D. Tremblay, Peter M. J. Douglas, Christina T. Halperin, Yves Gélinas   +3 more
wiley   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Above canopy and understory nitrogen additions lead to divergent spatio-temporal nitrogen retention patterns in a temperate forest

Communications Earth & Environment
Forest ecosystem responses to nitrogen (N) deposition depend on N fate, yet most simulated N deposition experiments focus on understory addition, overlooking canopy N processes. Here we compared canopy (CAN) and understory (UAN) N addition in a secondary
Zhichun Yang, Rossella Guerrieri, Nan Ye, Yilin Shao, Fei Yu, Tiezhu Jiao, Huichun Yang, Ji Chen, Mianhai Zheng, Ang Wang, Qiulong Yin, Zhanqing Hao, Qiong Chen, Zuoqiang Yuan   +13 more
doaj   +1 more source

Controlled Delivery and Light-Induced Release of Magic Spot Nucleotides in Escherichia coli. [PDF]

Angew Chem Int Ed Engl
We synthesized photocaged, clickable and isotope‐labeled “magic spot” Nucleotides and delivered them into Escherichia coli comparing different approaches. Light‐controlled release inside living cells enabled tracking of their conversion from pppGpp to ppGpp by capillary electrophoresis mass spectrometry and revealed their impact on the growth rate of a
Popp C, Moser P, Schwoerbel A, Liu X, Freitag J, Sarmah P, Prucker I, Zscherp R, Wang X, Klahn P, Koch HG, Bange G, Jessen HJ.   +12 more
europepmc   +2 more sources

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Spatially resolved mapping of histones reveals selective neuronal response in Rett syndrome

The FEBS Journal, EarlyView.
Loss of Mecp2 function is associated with Rett syndrome (RTT). MeCP2 regulates chromatin, yet its influence on histone composition and dynamics is unclear. Combining MALDI‐MSI with LCM–LC–MS/MS, we mapped histone proteoforms across the dentate gyrus, cornu ammonis, and cerebellum in two mouse models of RTT.
Frederike Schäfer, Guiseppa de Rocco, Moritz Völker‐Albert, Ignasi Forne, Nicoletta Landsberger, Axel Imhof, Shibojyoti Lahiri   +6 more
wiley   +1 more source