Results 171 to 180 of about 68,942 (307)

Fecal Steroids as Tracers of Human Population and Waste Management Practices at the Ancient Maya City of Ucanal, Guatemala

open access: yesArchaeometry, EarlyView.
ABSTRACT Geochemical data compiled from dried sediments from three water reservoirs at the ancient Maya city of Ucanal, Petén, Guatemala, reveal low to undetectable fecal biomarker concentrations. These low concentrations may be the result of the aerobic decay of sterols combined with well‐managed waste disposal practices.
Jean D. Tremblay   +3 more
wiley   +1 more source

wr.c.15N.6.7.3.1

open access: yes, 1940
Baker company ...

core  

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

open access: yesThe FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak   +7 more
wiley   +1 more source

AcrIIA8 is a putative phage structural protein of the HTJ2 family that does not inhibit Streptococcus pyogenes Cas9. [PDF]

open access: yesProtein Sci
Abstract Anti‐CRISPR (Acr) proteins are phage‐encoded anti‐defense factors that suppress CRISPR‐Cas immunity in bacteria. AcrIIA8 was previously identified as an inhibitor of Streptococcus pyogenes Cas9 (SpyCas9) through functional assays of metagenomic libraries. Here, we report that AcrIIA8 does not inhibit SpyCas9 in biochemical assays under a range
An SY, Kim I, Hong SH, Kim EH, Suh JY.
europepmc   +2 more sources

wr.c.15N.11.4.1.2

open access: yes, 1942
AA

core  

Spatially resolved mapping of histones reveals selective neuronal response in Rett syndrome

open access: yesThe FEBS Journal, EarlyView.
Loss of Mecp2 function is associated with Rett syndrome (RTT). MeCP2 regulates chromatin, yet its influence on histone composition and dynamics is unclear. Combining MALDI‐MSI with LCM–LC–MS/MS, we mapped histone proteoforms across the dentate gyrus, cornu ammonis, and cerebellum in two mouse models of RTT.
Frederike Schäfer   +6 more
wiley   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

open access: yesImmunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez   +10 more
wiley   +1 more source

Hydrazinoacetic acid is a biosynthetic precursor of the bacterially produced nitramine, <i>N</i>-nitroglycine. [PDF]

open access: yesAppl Environ Microbiol
Padilla G   +6 more
europepmc   +1 more source

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