Results 91 to 100 of about 80,061 (261)

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin   +11 more
wiley   +1 more source

Staphylococcus cohnii subsp. urealyticus strain X2 16S ribosomal RNA gene, partial sequence. [PDF]

open access: yes, 2007
Staphylococcus cohnii subsp. urealyticus strain X2 16S ribosomal RNA gene, partial sequence. GenBank: EF424598.
PRETTI, CARLO   +6 more
core  

NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis

open access: yesAdvanced Science, EarlyView.
In the American cockroach, NFYB acts as a spatiotemporin that translates distinct hormonal cues into tissue‐specific allometry. Juvenile hormone activates NFYB in the early fat body, while 20‐hydroxyecdysone induces it in late wing pads. NFYB then promotes protein biosynthesis via core translational machinery, driving differential growth across the ...
Fangfang Liu   +11 more
wiley   +1 more source

Staphylococcus schleiferi subsp. coagulans strain X60 16S ribosomal RNA gene, partial sequence [PDF]

open access: yes, 2007
Staphylococcus schleiferi subsp. coagulans strain X60 16S ribosomal RNA gene, partial sequence GenBank: EF424582.
PRETTI, CARLO   +6 more
core  

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

open access: yesAdvanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li   +10 more
wiley   +1 more source

¹⁵N stable isotope probing of pulp and paper wastewaters [PDF]

open access: yes, 2008
Stable isotope probing (SIP) is an established technique that can be applied to identify the metabolically active micro-organisms within a microbial population.
Addison, Sarah Louise
core  

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang   +8 more
wiley   +1 more source

Staphylococcus hominis subsp. hominis strain X29 16S ribosomal RNA gene, partial sequence [PDF]

open access: yes, 2007
Staphylococcus hominis subsp. hominis strain X29 16S ribosomal RNA gene, partial sequence GenBank: EF424591.
PRETTI, CARLO   +6 more
core  

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

open access: yesAdvanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu   +12 more
wiley   +1 more source

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