Results 311 to 320 of about 186,676 (349)

Akkermansia muciniphila‐derived hypoacylated rough‐type lipopolysaccharides alleviate diet‐induced obesity via activation of TLR4−IL‐23−IL‐22 immune axis

iMeta, EarlyView.
This study demonstrates that hypoacylated, rough‐type lipopolysaccharides (LPS) derived from Akkermansia muciniphila strain HW07 (ALPS) alleviates diet‐induced obesity. ALPS acts as a weak TLR4 agonist and significantly reduces weight gain, improves metabolic parameters, and restores gut barrier integrity in obese mice.
Li Sun, Yuting Zhang, Wang Dong, Jingzu Sun, Tao Wang, Fei Shao, Huanqin Dai, Junjie Han, Wenzhao Wang, Shuo Wang, Tong Zhao, Liangliang Wang, Chang Liu, Shuangjiang Liu, Hongwei Liu   +14 more
wiley   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, EarlyView.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source

Expression of De Novo Open Reading Frames in Natural Populations of Drosophila melanogaster

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
We show that newly‐evolved, expressed open reading frames (neORFs) identified in a set of inbred Drosophila melanogaster lines are also expressed in multiple tissues and developmental stages of pooled population samples from Europe and Africa, although differential expression of neORFs between populations is often tissue‐ or stage‐specific. ABSTRACT De
Amanda Glaser‐Schmitt, Marie Lebherz, Ezgi Saydam, Erich Bornberg‐Bauer, John Parsch   +4 more
wiley   +1 more source

Calcium butyrate efficacy in pediatric irritable bowel syndrome: Randomized placebo‐controlled multiomics‐based clinical trial

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, and treatment involves nonpharmacological and pharmacological therapies, even if there is no optimal therapy. This randomized, placebo‐controlled, double‐blind trial aimed to evaluate the efficacy of calcium butyrate supplementation in ...
Fernanda Cristofori, Francesco Maria Calabrese, Ilaria Iacobellis, Monica Santamaria, Giuseppe Celano, Ilario Ferrocino, Emanuela Di Sabato, Rocco Pergola, Vanessa N. Dargenio, Leonardo Paulucci, Maria De Angelis, Ruggiero Francavilla   +11 more
wiley   +1 more source

Effects of a high‐fat diet on gut microbiota and possible implications for bone health in male Wistar rats

Lipids, EarlyView.
Abstract Diet plays an important role in the composition of gut microbiota. Emerging research suggests that bone homeostasis can also be influenced by the gut microbiota. The aim of this study was to assess possible alterations in gut microbiota in an experimental obesity model induced by a high‐fat diet (HFD) and the possible effects on parameters of ...
Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Renata Meca, Horácio Montenegro, Lilian Cuppari, Martin H. de Borst, Ita Pfeferman Heilberg   +6 more
wiley   +1 more source

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Interaction of antibiotics with functional sites in 16S ribosomal RNA

Nature, 1987
Chemical footprinting shows that several classes of antibiotics (streptomycin, tetracycline, spectinomycin, edeine, hygromycin and the neomycins) protect concise sets of highly conserved nucleotides in 16S ribosomal RNA when bound to ribosomes. These findings have strong implications for the mechanism of action of these antibiotics and for the ...
Danesh Moazed, Harry F. Noller
openaire   +4 more sources

Secondary Structure of 16 S Ribosomal RNA

Science, 1981
A secondary structure model for 16 S ribosomal RNA which is based on available chemical, enzymatic, and comparative sequence data shows good agreement between constraints dictated by the model and a wide variety of experimental observations.
Carl R. Woese, Harry F. Noller
openaire   +4 more sources