Results 61 to 70 of about 109,607,141 (279)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Two-Phase Master Sintering Curve for 17-4 PH Stainless Steel

, 2016
The sintering behavior of 17-4 PH stainless steel has been efficiently characterized by a two-phase master sintering curve model (MSC). The activation energy for the sintering of gas-atomized and water-atomized 17-4 PH powders is derived using the mean ...
Blaine, D.C, German, Randall M., Im Doo Jung, German, R.M., Blaine, Deborah C., Ha, Sangyul, Ha, S, Seong Jin Park, Bollina, R, Sangyul Ha, Deborah C. Blaine, Jung, Im Doo, Bollina, Ravi, Ravi Bollina, Randall M. German, Jung, I.D, Park, S.J, Park, Seong Jin   +17 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Experimental design approach to optimize selective laser melting of martensitic 17-4 PH powder: part I - single laser tracks and first layer

, 2012
International audiencePurpose - The purpose of this paper is to investigate the effect of main process parameters of selective laser melting (SLM) technology on single lines and single layers manufactured from 17-4 PH martensitic powder using the ...
Cicala, E., Averyanova, M., Bertrand, Ph, Grevey, Dominique   +3 more
core   +1 more source

Effect of localized thermal history on martensitic microstructure and microhardness variation in wire-arc additively manufactured 17–4 PH stainless steel beads

Scientific Reports
Wire arc additive manufacturing (WAAM) enables rapid and low-cost fabrication of large steel components. However, cumulative thermal history along a single bead can cause significant variations in microstructure and properties at fixed parameters, a ...
Annayath Maqbool, Abul Fazal M. Arif, Ahmed J. Qureshi, Irfan Ahmed, Abba A. Abubakar   +4 more
doaj   +1 more source

Tensile Performance Sensitivity to Variations of Standard 17-4 PH Heat Treatments on LPBF-Produced Material

Metals
Standard heat treatments for metals of a particular composition are typically designed with the assumption of a conventional starting microstructure, such as that produced by casting or wrought processing.
Ben Brown, Cory Read, Joseph Newkirk, Frank Liou   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source