Results 71 to 80 of about 11,673 (224)

Non-Steroidal Drug Interferences in a Quantitative Multisteroid LC-MS/MS Assay

Cells, 2023
Screening for possible interferences from steroidal compounds other than the target analytes (endogenous or exogenous) is well established in LC-MS/MS assay development for steroid quantification in a routine clinical setting. However, interferences from
Valentin Braun, Hermann Stuppner, Christoph Seger   +2 more
doaj   +1 more source

Resonance Raman Spectroscopy Reveals that Substrate Structure Selectively Impacts the Heme-Bound Diatomic Ligands of CYP17 [PDF]

, 2013
An important function of steroidogenic cytochromes P450 is the transformation of cholesterol to produce androgens, estrogens, and the corticosteroids.
Gregory, Michael C., Kincaid, James R., Mak, Piotr J., Sligar, Stephen G.   +3 more
core   +2 more sources

Homozygous Pathogenic Variant in Elongation Factor‐Like 1 (EFL1) as a Causal Factor in Shwachman‐Diamond Syndrome 2 in a Palestinian Child, With Distinct Ocular Manifestations

Molecular Genetics &Genomic Medicine, Volume 14, Issue 5, May 2026.
We report a Palestinian female infant with a homozygous pathogenic EFL1 variant (c.3284G>A; p.Arg1095Gln) causing Shwachman–Diamond syndrome type 2 (SDS2). Beyond the classical features of pancytopenia, exocrine pancreatic insufficiency, and growth failure, the patient showed previously unreported ocular manifestations—stage 2–3 retinopathy of ...
Ibrahim Taha, Antonella Minelli, Cesare Danesino, Abdelrahman Swalmeh, Khalil Huraibat, Liana Al‐Labadi, Rema Obar, Khaled R. Beshtawi, Lubna Abu Samrah, Yousef Awlad Mohammad, Aya Farah, Abdulrahman Obar, Mutasem Khalaf, Orwa Nasser   +13 more
wiley   +1 more source

Features of endocrine status in adolescents with multiple sclerosis

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Introduction. A number of authors have shown changes of hormonal status in adults with multiple sclerosis (MS) compared to healthy volunteers. At the same time, there are few such studies in the pediatric population, conducted on small groups, with ...
V. M. Lebedev, N. A. Totolyan
doaj   +1 more source

Hiperplasia adrenal congênita: dosagem da 17-hidroxiprogesterona basal para seleção e casos para realização do teste de estímulo com ACTH sintético Congenital adrenal hyperplasia: measurement of basal 17-hydroxyprogesterone as a screening test to select patients for the synthetic ACTH provocative test

Revista Brasileira de Ginecologia e Obstetrícia, 2004
OBJETIVOS: avaliar se os níveis de 17-hidroxiprogesterona podem predizer o resultado do teste de estímulo como diagnóstico de hiperplasia adrenal congênita, forma tardia. MÉTODOS: foram incluídas no estudo e avaliadas retrospectivamente 122 pacientes com
Lúcia Helena Coelho Nóbrega, Josivan Gomes de Lima, Maria Lúcia Coelho Nóbrega, Ana Luiza de Souza Brito, Raphael Pinto de Mendonça   +4 more
doaj   +1 more source

Cardiovascular risk factors in children and adolescents with congenital adrenal hyperplasia

Advanced Biomedical Research, 2021
Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder caused by impaired steroidogenesis. Glucocorticoid treatment with increased androgens may lead to cardiovascular and metabolic effects in these patients.
Elham Hashemi Dehkordi, Sara Khaheshi, Neda Mostofizadeh, Mahin Hashemipour   +3 more
doaj   +1 more source

Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo [PDF]

, 2009
Background 17alpha-hydroxylase/17, 20-lyase encoded by CYP17 is the key enzyme in androgen biosynthesis pathway. Previous studies demonstrated the accentuation of the enzyme in patients with polycystic ovary syndrome (PCOS) was the most important ...
Yi Li, Xiao-yan Liang, Li-na Wei, Yong-lao Xiong, Xing Yang, Hui-gan Shi, Zi-hong Yang   +6 more
core   +1 more source

Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR‘G' subfamily, recent cryo‐EM structures of the androgens 5α‐dihydrotestosterone (5α‐DHT) and methenolone bound to ADGRD1 revealed a putative steroid ...
Bethany Fleming, Abdul‐Akim Guseinov, Irina G. Tikhonova, Graeme Milligan, Nicole A. Perry‐Hauser   +4 more
wiley   +1 more source

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen   +5 more
wiley   +1 more source

The value of serum levels of dehydroepiandrosterone sulfate as a screening test for late-onset congenital adrenal hyperplasia [PDF]

Einstein (São Paulo), 2006
Objective: To evaluate the use of serum level of dehydroepiandrosteronesulfate as a screening test for late-onset congenital adrenal hyperplasia.Methods: Fourteen hirsute women with elevated serum levels ofdehydroepiandrosterone sulfate, 17 hirsute women
Marcos Yorghi Khoury, Edmund Chada Baracat, Dolores Perovano Pardini, Rita de Cássia Castro, Odilon Victor Porto Denardin, Geraldo Rodrigues de Lima   +5 more
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