Results 1 to 10 of about 275 (120)

Rational Design of Thermophilic Cyp119 for Progesterone Hydroxylation by in Silico Mutagenesis and Docking Screening

, 2023
Steroid-based chemicals can affect the metabolism, immune functions, and development of sexual characteristics. Because of these effects, steroid derivatives are widely used in the pharmaceutical industry.
Güralp, Gülce, Kestevur Doğru, Ekin, Sürmeli, Nur Başak, Uyar, Arzu, Doğru, Ekin Kestevur   +4 more
core   +1 more source

Influence of 16 -Hydroxyprogesterone, 20 -Hydroxyprogesterone and 20 -Hydroxyprogesterone on Progesterone Activity in a Bio-Assay

Experimental Biology and Medicine, 1970
SummaryIn the B6D2F1 mouse the MED by Hooker-Forbes bioassay of progesterone was 0.0005 μg; of 20α-hydroxyprogesterone, 0.0004 μg; of 20β-hydroxyprogesterone, 0.00006 μg; of 16α-hydroxyprogesterone, 2.0 μg. Progestin activity of mixtures of progesterone with 16α-hydroxyprogesterone, 20α-hydroxyprogesterone, and 20β-hydroxyprogesterone was measured by ...
openaire   +1 more source

OUABAIN RECEPTOR BINDING OF HYDROXYPROGESTERONE DERIVATIVES [PDF]

British Journal of Pharmacology, 1979
A specific and sensitive radioreceptor assay has been devised which is based on high affinity, saturable binding of 9 nm[3H]‐ouabain to the total particulate fraction isolated from dog heart. Ouabain and other cardiac glycosides, including the aglycones, were about equipotent in their ability to displace [3H]‐ouabain from its receptor, the IC50s ...
E, Chow, R S, Kim, F S, Labella, G, Queen   +3 more
openaire   +2 more sources

Effect of weekly 17-hydroxyprogesterone caproate on small for gestational age among pregnant women with HIV in Zambia. [PDF]

AIDS, 2022
Conner MG, Vwalika B, Freeman BL, Sebastião YV, Mabula-Bwalya CM, Cole SR, Stringer EM, Kasaro MP, Stringer JSA, Price JT.   +9 more
europepmc   +1 more source

Deciphering the mechanisms of action of progesterone in breast cancer. [PDF]

Oncotarget, 2023
Chakravorty G, Ahmad S, Godbole MS, Gupta S, Badwe RA, Dutt A.   +5 more
europepmc   +1 more source

Relationship between plasma concentration of 17-hydroxyprogesterone caproate and gestational age at preterm delivery. [PDF]

Am J Obstet Gynecol MFM, 2023
Caritis SN, Costantine MM, Clark S, Stika CS, Kiley JW, Metz TD, Chauhan SP, Venkataramanan R, Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetric-Fetal Pharmacology Research Centers Network.   +8 more
europepmc   +1 more source

Regional differences in utilization of 17α-hydroxyprogesterone caproate (17-OHP). [PDF]

J Perinat Med, 2022
Hart JM, Hakim JB, Wylie BJ, Beam AL.
europepmc   +1 more source

A Possible Mechanism of Action of 17α-Hydroxyprogesterone Caproate: Enhanced IL-10 Production. [PDF]

Am J Perinatol, 2023
Megli CJ, Hauspurg A, Venkataramanan R, Caritis SN.   +3 more
europepmc   +1 more source

Addressing a broken drug pipeline for preterm birth: why early preterm birth is an orphan disease. [PDF]

Am J Obstet Gynecol, 2023
Baxter C, Crary I, Coler B, Marcell L, Huebner EM, Rutz S, Adams Waldorf KM.   +6 more
europepmc   +1 more source

What now? A critical evaluation of over 20 years of clinical and research experience with 17-alpha hydroxyprogesterone caproate for recurrent preterm birth prevention. [PDF]

Am J Obstet Gynecol MFM, 2023
Manuck TA, Gyamfi-Bannerman C, Saade G.
europepmc   +1 more source