Results 191 to 200 of about 140,614 (262)

The characteristics of perivascular proinflammation in 4‐repeat tauopathies

Brain Pathology, EarlyView.
The spatial distribution of perivascular proinflammation differs between PSP and CBD: PSP shows a predominance in basal ganglia (BG), whereas CBD demonstrates more widespread involvement of both BG and superior/middle frontal gyrus (S/M‐FG). PSP exhibits profound proinflammatory activation around venules while CBD affects a comparable magnitude around ...
Mu‐Hui Fu, Gokhan Uruk, Rodolfo G. Gatto, R. Ross Reichard, Jennifer L. Whitwell, Keith A. Josephs   +5 more
wiley   +1 more source

Head-to-Head Comparison Between [¹⁸F]FDG and [⁶⁸Ga]Ga-Pentixafor PET/CT in Multiple Myeloma: A Systematic Review and Meta-Analysis. [PDF]

Cancers (Basel)
Albano D, Tasevski S, Rapa M, Nanni C, Treglia G.   +4 more
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Nonsteroidal ¹⁸F-Labeled PET Tracer for Imaging Androgen Receptors. [PDF]

J Nucl Med
Jallinoja VIJ, Mun JS, Campanella A, Sasson A, Kalidindi TM, Caxeiro G, Veach DR, Lyashchenko S, Schöder H, Pillarsetty NVK.   +9 more
europepmc   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Macrophage-mediated inflammation and microcalcification are associated with abdominal aortic aneurysm progression and clinical events. [PDF]

Br J Surg
Forsythe RO, McBride OMB, Robson JMJ, Vesey AT, Winarski AC, Weston C, Debono S, Semple SI, Gray CD, MacGillivray TJ, Brittenden J, Roditi G, Stuart W, van Beek EJR, Tambyraja AL, Williams MC, Dweck MR, Newby DE.   +17 more
europepmc   +1 more source

Metabolic remodelling in anthracycline cardiotoxicity: mechanisms and therapeutic insights

British Journal of Pharmacology, EarlyView.
Cardiac metabolic remodelling in anthracycline‐induced cardiomyopathy and metabolically oriented cardioprotective strategies. Schematic representation of substrate utilization, mitochondrial bioenergetic function and metabolic flexibility in the healthy heart, in anthracycline‐induced cardiomyopathy and under potential cardioprotective interventions ...
Giulia Guerra, Francesco Niro, Marco Mergiotti, Giovanni Gavatorta, Emilio Hirsch, Alessandra Ghigo   +5 more
wiley   +1 more source

Widespread skeletal muscle involvement on 18F-FDG PET/CT in nocardiosis. [PDF]

Rheumatology (Oxford)
Erkek Yilmaz M, Kenar-Artin G, Yarkan-Tugsal H.   +2 more
europepmc   +1 more source