Results 201 to 210 of about 779,586 (254)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

¹H NMR for Comparative Metabolic Analysis of Whey and WPC-80. [PDF]

Metabolites
Sousa I, Meoni G, Tenori L, Pozza M, De Marchi M, Niero G.   +5 more
europepmc   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

¹H NMR-based metabolomics reveals metabolic changes in porcine ingesta and serum during Ascaris suum infection. [PDF]

Parasit Vectors
Wagner L, Springer A, Koehler S, Brüggemann DA, Strube C.   +4 more
europepmc   +1 more source

Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction

Advanced Science, EarlyView.
Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen, Bapan Biswas, Apinya Ngoipala, Julia Wiktor, Ujjwal Pal, Shalini Singh   +5 more
wiley   +1 more source

Correction: ¹H-NMR serum metabolomic profiling from clinical routine identifies signatures of progressive melanoma metastasis. [PDF]

Sci Rep
Gellrich FF, Hufnagel C, Funk AM, Jonas S, Altmann H, Hobelsberger S, Steininger J, Rauschenberg R, Garzarolli M, Lehr S, Pöschman L, Biedermann P, Schatz JS, Feige C, Tasdogan A, Chavakis T, Beissert S, Meier F, Mirtschink P, Steiner G.   +19 more
europepmc   +1 more source

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

Advanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang, Shaowen Zhuo, Binyu Song, Jinan Chen, Xin Zhao, Sijia Li, Shuang You, Dong Jiang, Yuedong Chen, Juanli Dang, Tong Wang, Baolin Guo, Zhou Yu, Baoqiang Song   +13 more
wiley   +1 more source

¹H NMR-Based Metabolomics and Machine Learning Reveal Candidate Metabolic Markers Associated with <i>Coffea arabica</i> Genealogical Groups. [PDF]

Foods
Malta MR, Carvalho GR, Nadaleti DHS.
europepmc   +1 more source

Programming Structural Symmetry and Emission in Low‐Dimensional Hybrid Perovskites via Time and Temperature

Advanced Science, EarlyView.
We demonstrate programmable structural symmetry and emission in benzylammonium‐based low‐dimensional hybrid perovskites. Continuous shaking transforms orthorhombic platelets into a lower‐symmetry monoclinic phase with broadband emission, whereas thermal activation drives the reverse pathways toward a higher‐symmetry configuration resembling the ...
Luiz G. Bonato, Sirous Khabbaz Abkenar, Balaji Dhanabalan, Quentin Evrard, Luca Goldoni, Sergio Marras, Giorgio Divitini, Milena P. Arciniegas   +7 more
wiley   +1 more source

1H-NMR-based metabolomics identifies disrupted betaine metabolism as distinct serum signature of pre-frailty. [PDF]

NPJ Aging
Marino C, Imarisio A, Gasparri C, Napolitano E, Di Maio A, Avenali M, Buongarzone G, Galandra C, Picascia M, Grimaldi M, Errico F, Rondanelli M, D'Ursi AM, Valente EM, Usiello A.   +14 more
europepmc   +1 more source