Results 41 to 50 of about 778,058 (302)

Microwave-Assisted Regioselective Synthesis and 2D-NMR Studies of New 1,2,3-Triazole Compounds Derived from Acridone

open access: yesJournal of Chemistry, 2021
A simple and mild protocol towards the synthesis of new 1,2,3-triazole compounds derived from acridone has been developed via regiospecific 1,3-dipolar cycloaddition reaction between 10-(prop-2-yn-1-yl)acridone derivatives and aromatic azides using CuI ...
Mohammed Aarjane   +3 more
doaj   +1 more source

1H-NMR based lipid profiling of Gossypium hirsutum seed oil at different developmental stages

open access: yesCurrent Research in Green and Sustainable Chemistry, 2021
1H-NMR spectroscopy is emerging as powerful robust analytical technique in analyzing bio constituents present in plants. It offers non-invasive method for identification and quantification of several Phyto-constitutes in a single step without much pre ...
Nikita J. Kurkuri   +3 more
doaj   +1 more source

Metabolic profiling framework for discovery of candidate diagnostic markers of malaria [PDF]

open access: yes, 2013
Despite immense efforts to combat malaria in tropical and sub-tropical regions, the potency of this vector-borne disease and its status as a major driver of morbidity and mortality remain undisputed.
Utzinger, Juerg   +8 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Structural Elucidation of Hybutimibe

open access: yesChinese Journal of Magnetic Resonance
The structure of hybutimibe was analyzed by ultraviolet absorption spectroscopy, infrared absorption spectroscopy, mass spectrometry, nuclear magnetic resonance (1H NMR, 13C NMR, DEPT, 1H-1H COSY, 1H-1H NOESY, 1H-13C HSQC and 1H-13C HMBC) spectroscopy ...
XU Xiaojie   +6 more
doaj   +1 more source

A Wide-Line Solid-State 1H NMR Study of Phase Structures of Semi-Crystalline Polymers

open access: yesChinese Journal of Magnetic Resonance, 2019
Wide-line solid-state proton nuclear magnetic resonance (1H NMR) spectrometry is a classical technique to study the phase structures of semi-crystalline polymers.
WU Jin-ze   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Biological 1H NMR spectroscopy

open access: yesComparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1988
Proton nuclear magnetic resonance spectroscopy (1H NMR) is a powerful analytical method used to identify and quantitate chemical compounds. In recent years, it has been used to study rates of metabolism in microbes, isolated perfused tissues, intact animals, and human beings.
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

1H-NMR metabolomics for wine screening and analysis

open access: yesOENO One, 2023
The number of metabolomic studies has grown steadily over the last twenty years. Among the fields of application, food sciences are broadly represented.
Inès Le Mao   +2 more
doaj   +1 more source

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