Results 71 to 80 of about 1,362,496 (337)

Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]

, 2013
The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E., Arrowsmith J., Barvaux V. A., Boberg F., Boyd M. R., Bunz F., Damera K., Darkes M. J. M., De K., Denny B. J., Dimitrios Pletsas, Dinca E. B., Elrashied A. E. Garelnabi, Garelnabi E. A. E., Hirose Y., Honnalli S. S., Judson P. L., Karran P., Karran P., Kotera M., Leteurtre F., Li Li, Liu L., McElhinney R. S., McGarrity J. F., Mladek A. C., Nishizuka S., Pletsas D., Richard T. Wheelhouse, Roger M. Phillips, Sarkaria J. N., Schmidt B. F., Schmiedekamp A., Shealy Y. F., Siddiqui A. A., Smith R. H., Stevens M. F. G., Svilar D., Wang Y., Wheelhouse R. T., Wheelhouse R. T., Zhang J., Zhang J.   +42 more
core   +1 more source

MnI‐Functionalized Covalent Organic Framework as Efficient Electrocatalyst for CO2 Reduction in a Catholyte‐Free Zero‐Gap Electrolyzer

Advanced Functional Materials, EarlyView.
This work demonstrates the successful integration of a phenanthroline‐based 2D COF with MnI catalytic sites into a catholyte‐free membrane‐electrode‐assembly cell for CO2 electroreduction. The crystalline COF actively suppresses Mn⁰–Mn⁰ dimerization, achieving a turnover frequency of 617 h⁻¹ at 2.8 V (full‐cell potential), and enabling stable operation.
Laura Spies, Marcos Eduardo G. Carmo, Gonçalves J. Marrenjo, Stephan Reuther, Patrick Ganswindt, Antonio Otavio T. Patrocinio, Thomas Bein, Osmando F. Lopes, Jenny Schneider   +8 more
wiley   +1 more source

Reactivity of TEMPO anion as a nucleophile and its applications for selective transformations of haloalkanes or acyl halides to aldehydes [PDF]

, 2004
Sodium 2,2,6,6-tetramethylpiperidine-N-oxide (TEMPO−Na+), generated by reduction of TEMPO· with sodium naphthalenide in THF, reacted with alkyl halides or acyl halides to produce O-alkylated or acylated TEMPOs, which were in turn oxidized with ...
Allen, Anderson, Boger, Braslau, Braslau, Gilbert, Hawker, Henry-Riyad, Hiroyuki Kawafuchi, Hudlicky, Hunter, Inokuchi, Jahn, Johnstone, Kersey, Kilenyi, Kruse, Matyjaszewski, Nahm, Ollivier, Page, Paquette, Ren, Rossi, Saunders, Schämann, Semmelhack, Sholle, Skene, Studer, Togo, Tsutomu Inokuchi, Uneyama, Wetter, Whitesides, Winterfeldt   +35 more
core   +1 more source

Modulating Two‐Photon Absorption in a Pyrene‐Based MOF Series: An In‐Depth Investigation of Structure–Property Relationships

Advanced Functional Materials, EarlyView.
This study investigates H4TBAPy‐based metal–organic frameworks (MOFs) ‐ NU‐1000, NU‐901, SrTBAPy, and BaTBAPy ‐ for multiphoton absorption (MPA) performance. It observes topology‐dependent variations in the 2PA cross‐section, with BaTBAPy exhibiting the highest activity.
Simon N. Deger, Helmy Pacheco Hernandez, Yang Cui, Hongxing Hao, Vanessa Ramm, David C. Mayer, Khai‐Nghi Truong, Roland A. Fischer, Jürgen Hauer, Mariana Kozlowska, Alexander Pöthig   +10 more
wiley   +1 more source

Unveiling the impact of second-order 1H-17O Quadrupolar-Dipolar interaction on solid-state NMR spectroscopy

Journal of Magnetic Resonance Open
Recent advances in the 17O-enrichment techiques and high-resolution nuclear magnetic resonance (NMR) methods have opened new opportunities to utilize 17O NMR to disentangle the zeolitic structure−property relationship that has not been well resolved ...
Yi Ji, Kuizhi Chen, Aijing Hao, Guangjin Hou   +3 more
doaj   +1 more source

Spectral Analysis of a 1,4-Thiazinamide FKBPs Ligand

Chinese Journal of Magnetic Resonance, 2018
(3R)-4-[(4-methylphenylsulfonyl)]-1,4-thiazine-3-acyl-[(2R)-2-amino-4-methyl]-pentanoic acid isopropyl ester (ID:HD5-6) is a ligand of FK506 binding proteins (FKBPs), which we developed and had proprietary intellectual property rights for.
JIANG Dan, WANG Wei, BI Qian-nan, SU Dan-dan   +3 more
doaj   +1 more source

Practical guides for 1H detected solid-state NMR under fast MAS for small molecules

Journal of Magnetic Resonance Open, 2022
This primer article introduces a practical guide for setting up 1H detection solid-state NMR experiments under fast MAS conditions for small molecules. Sample independent adjustment/calibration including magic angle adjustment, shimming, radio-frequency ...
Yusuke Nishiyama, Nghia Tuan Duong
doaj   +1 more source

Maize tricin-oligolignol metabolites and their implications for monocot lignification [PDF]

, 2016
Lignin is an abundant aromatic plant cell wall polymer consisting of phenylpropanoid units in which the aromatic rings display various degrees of methoxylation.
Boerjan, Wout, del Río, José Carlos, Lan, Wu, Lu, Fachuang, Morreel, Kris, Ralph, John, Rencoret, Jorge, Vermerris, Wilfred, Voorend, Wannes   +8 more
core   +2 more sources

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source

Application of NMR Screening Methods with 19F Detection to Fluorinated Compounds Bound to Proteins

Magnetochemistry, 2017
The combinational use of one-dimensional (1D) NMR-based screening techniques with 1H and 19F detections were applied to a human serum albumin–diflunisal complex.
Kazuo Furihata, Moe Usui, Mitsuru Tashiro   +2 more
doaj   +1 more source