Results 111 to 120 of about 120,417 (300)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

A Rare Allele of ST5 From Wild Rice Enhances Salt Tolerance in Rice

Advanced Science, EarlyView.
A novel salt‐tolerance gene ST5W, characterized by a unique 36‐bp promoter insertion, is found exclusively in a small subset of Oryza rufipogon and is absent in cultivated rice. Field trials confirm ST5W significantly enhances rice yield across diverse genetic backgrounds under saline conditions.
Meng Xing, Jingfen Huang, Qiaoling Yuan, Ziyi Yang, Yanyan Wang, Mingchao Zhao, Yamin Nie, Rui Xu, Hongge Qian, Wenxi Chen, Qiaoling Zhang, Qi Du, Leiyue Geng, Yapeng Li, Ziyi Chen, Shizhuang Wang, Like Lou, Haiyuan Peng, Chongke Zheng, Xianzhi Xie, Xiaoming Zheng, Lifang Zhang, Lianguang Shang, Jiaqiang Sun, Qian Qian, Qingwen Yang, Weihua Qiao   +26 more
wiley   +1 more source

The design of an automated workflow for metadata generation [PDF]

, 2010
The important role of digital resources relies on whether metadata is available and has been correctly catalogued and indexed so that the user can discover and use geospatial datasets.
Wachowicz, Monica, Miguel Bernabé-Poveda, Miguel Manso-Callejo, Bernabe Poveda, Miguel Angel, Manso Callejo, Miguel Ángel, Mónica Wachowicz   +5 more
core   +2 more sources

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Phase Fraction Modulation Enhances Li+/Na+ Diffusion Disparity in Spent LiFePO4 Cathodes for Efficient Lithium Extraction from Brine

Advanced Science, EarlyView.
A direct cascaded utilization strategy for spent LiFePO4 batteries efficiently extracts lithium from brine, embodying the “urban mining” concept. Phase fraction modulation revealed its significant impact on local bond lengths of crystal structure and the Li/Na diffusion energy barrier, identifying the best material (Li0.19FePO4) for lithium extraction.
Ruiqi Yin, Qihan Huang, Jiayu Hao, Guosheng Li, Guoxing Ren, Dongfu Liu, Zhongwei Zhao, Wenhua Xu   +7 more
wiley   +1 more source

UWE – Scion collaboration: 1st generation MFCs

, 2019
Slide deck capturing the collaboration between UWE and ...
Ieropoulos, Ioannis, Francois, Christopher   +1 more
openaire   +1 more source

Transgenerational genetic and epigenetic changes induced by gamma-ray in Fagopyrum species

BMC Plant Biology
Background DNA changes induced by stress may be stable through cell division and passed to subsequent generations. Plant improvement programs require that individuals develop a new heritable trait.
Katarzyna Sala-Cholewa, Magdalena Rojek-Jelonek, Jolanta Kwasniewska   +2 more
doaj   +1 more source

Progress in the fabrication of the next-generation soft glass microstructured optical fibers [PDF]

, 2008
This paper was presented at the 1st Workshop on Specialty Optical Fibers and Their Applications, Sao Pedro, Sp, Brazil, 20-22 August, 2008.We report the fabrication of new soft glass microstructured optical fibers for sensing, high-nonlinearity and mid ...
Tanya M. Monro, Heike Ebendorff-Heidepriem, Moore, R., Monro, T., Ebendorff-Heidepriem, H., Cristiano M. B. Cordeiro, Roger C. Moore, Christiano J. S. de Matos   +7 more
core   +1 more source

Interfacial Polysulfide Confinement via Spatially Controlled Sulfonated Metal–Organic Polyhedra Coatings in Lithium–Sulfur Batteries

Advanced Science, EarlyView.
Spatially controlled sulfonated metal–organic polyhedra (SMOP) coating on sulfur‐loaded hollow carbon spheres form ultrathin, conformal interfacial barriers that selectively confine soluble polysulfides, stabilize sulfur redox, and suppress shuttle reactions.
Soyeon Ko, WooYeon Moon, Yuwei Zhu, Yuhui An, Yunyuan Lu, Sourayan Bal, Linqin Mu, Kyung Min Choi, Yoon Hwa   +8 more
wiley   +1 more source

Synergistic Dual Slip‐Link Toughening of a Water‐Rich Double Network Hydrogel Combining Slide‐Ring and Highly Entangled Networks

Advanced Science, EarlyView.
Two distinct slip‐link mechanisms – the slide‐ring pulley effect and highly entangled chains – are combined in a water‐rich double network hydrogel, achieving synergistic toughening, near‐complete reversibility, and exceptional friction tear resistance at >$>$91 wt.% water.
Subhankar Mandal, Saleh Assadi, Aseem Milind Visal, Ignacio Lorente Montero, Franck J. Vernerey, Carson J. Bruns   +5 more
wiley   +1 more source