Results 51 to 60 of about 7,321,433 (323)

Efficacy and safety of first- versus second-generation Bruton tyrosine kinase inhibitors in chronic lymphocytic leukemia: a systematic review and meta-analysis

Frontiers in Pharmacology
We conducted this first systematic review and meta-analysis to assess the competitive advantage of 2nd-generation Bruton tyrosine kinase inhibitors (BTKi) compared to 1st-generation BTKi in chronic lymphocytic leukemia (CLL).
Liyuan Ke, Su Li, Danxue Huang, Yan Wang
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Occurrence, bionomics and harmfulness of Chrysomela populi L. (Coleoptera, Chrysomelidae)

Journal of Forest Science, 2006
In 2003 to 2005, Chrysomela populi L. gradated on yearly cut Populus nigra var. italica in street alleys in Brno and elsewhere. Imagoes occurred on trees from the end of April or from the beginning of May. In rearing, the chrysomelid consumed unwillingly
J. Urban
doaj   +1 more source

The effect of yeast generations on fermentation, maturation and volatile compounds of beer

Czech Journal of Food Sciences, 2020
The aim of the study was to determine the effect of yeast generations on fermentation and maturation processes, the content of volatile compounds of beer and viability and vitality of yeast biomass on an industrial scale.
Krzysztof Kucharczyk, Tadeusz Tuszyński, Krzysztof Żyła, Czesław Puchalski   +3 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Abundance and Generation Determination of the Mango Shield Scale Milviscutulus mangiferae (Green) (Coccidae: Homoptera) an Invasive Coccid Infesting Mango Orchards at Qaliobiya Gevernorate [PDF]

Journal of Plant Protection and Pathology, 2018
The obtained results showed that the population fluctuation of Milviscutulus mangiferae (Green)was studied on mango trees for the two successive years (2016/2017) and (2017-2018) in Qalubyia Governorate, the activity of M. mangifrae took place from early
Maha Abd Elrazzik, Sahar Attia, Sahar Abd-Elaziz   +2 more
doaj   +1 more source

The Development of the In Situ Modification of 1st Generation Analytical Scale Silica Monoliths

Chromatographia, 2014
Analytical scale silica monoliths are commercially limited to three column selectivities (bare silica, C8 and C18). An in situ modification is reported in detail to overcome this barrier and allow for any functionality of choice to be bonded to the ...
A. Soliven, G. Dennis, E. Hilder, R. Shalliker, Paul G. Stevenson   +4 more
semanticscholar   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

COSTLY-DEFENSE SYSTEMS VERSUS PRODUCTIVE INVESTMENTS: THE CASE OF SINGAPORE’S 1st GENERATION MILITARY BUILD-UP (THE 1960s-1980s)

Jurnal Pertahanan: Media Informasi tentang Kajian dan Strategi Pertahanan yang Mengedepankan Identity, Nasionalism & Integrity, 2022
Choosing a costly defense over an economically productive investment is always a nightmare for national policymakers. Despite the dilemma, Singapore came up as an anomaly with its decision in investing a remarkable amount of defense budget, reaching 4.5%
Wirawan Hanindito Wicaksono, Ruslan Arief   +1 more
doaj   +1 more source

1st Battalion Machine Gun Corps Pass (Pvt. S Wolfe [sic]) [PDF]

, 1919
A 1st Battalion Machine Gun Corps soldier’s pass from September 22, 1919 granted the recipient (“Pvt. S. Wolfe [sic]) leave from their quarters to travel to Buttevant, a small village in Ireland that housed a military barracks.

core