Results 151 to 160 of about 2,354 (186)
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Biliary excretion of 2,4,5-trichlorophenoxyacetic acid in the rat
Toxicology Letters, 1982Urethane-anesthetized, male Sprague-Dawley rats were administered 25 mg/kg 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) intravenously. 6 h after administration, 15.7% of the dose was recovered in the bile. Reversed-phase high-performance liquid chromatography (HPLC) analysis of bile indicated that more than 85% of compound excreted in bile was unchanged
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The metabolism and distribution of 2,4,5-trichlorophenoxyacetic acid in female rats
Toxicology and Applied Pharmacology, 1973Abstract [1-14C]-2,4,5-Trichlorophenoxyacetic acid (2,4,5-T) was fed to pregnant and non-pregnant female rats at various dosages, and expired air, urine, feces, internal organs and tissues were analyzed for radioactivity. During the first 24 hr, 75 ± 7% of the radioactivity was excreted in the urine and 8.2 ± 4.6% in the feces.
S C, Fang +3 more
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Teratogenic studies on 2,4,5-trichlorophenoxyacetic acid in the rat and rabbit
Food and Cosmetics Toxicology, 1971Abstract Groups of Sprague-Dawley-derived rats received daily oral doses of 1, 3, 6, 12 or 24 mg 2,4,5-T/kg on days 6–15 of gestation. Groups of New Zealand White rabbits received daily oral doses of 10, 20 or 40 mg 2,4,5-T/kg on days 6–18 of gestation.
J L, Emerson +4 more
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Low doses of 2,4,5-trichlorophenoxyacetic acid are behaviorally teratogenic to rats
Experientia, 1983Pre-natal exposure of rats to 2,4,5-T has long-term effects on behavior. A test for novelty responding detects abnormalities after exposure to a single dose as low as 6 mg/kg on day 8 of gestation. This is well below doses reported to be morphologically teratogenic, and raises concern for human exposure.
M A, Crampton, L J, Rogers
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Toxicology and Applied Pharmacology, 1972
Abstract Chicks were able to tolerate large dietary doses of the herbicides 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), the only adverse effects being a reduction in food consumption and growth rate. A level of 5000 mg 2,4,5-T/kg proved fatal to chicks; a similar level of 2,4-D, while not resulting in death,
C C, Whitehead, R J, Pettigrew
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Abstract Chicks were able to tolerate large dietary doses of the herbicides 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), the only adverse effects being a reduction in food consumption and growth rate. A level of 5000 mg 2,4,5-T/kg proved fatal to chicks; a similar level of 2,4-D, while not resulting in death,
C C, Whitehead, R J, Pettigrew
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Disappearance of 2,4‐dichlorophenoxyacetic Acid and 2,4,5‐trichlorophenoxyacetic Acid from Soil
Soil Science Society of America Journal, 1952Abstract 2,4‐D was incubated in the laboratory with different depths of Duffield silty clay loam, and its disappearance therefrom was determined by a cucumber root elongation test. The lag period before onset of decomposition and the time required for complete decomposition of 2,4‐D increased with depth.
A. S. Newman, J. R. Thomas, R. L. Walker
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Herbicides. II. Crystal Structure of 2,4,5-T (2,4,5-Trichlorophenoxyacetic Acid)
Australian Journal of Chemistry, 1976The crystal structure of 2,4,5-T was determined by the symbolic addition method. 1741 reflections, of which 1326 were considered observed, were collected on a four-circle diffractometer. Crystals are triclinic, Pi, with z = 2, in a cell of dimensions: a 1089.5(6), b 684.8(3), c 683.8(3) pm, a 81.33(4)°, ß 78.90(4)°, ? 83.04(4)°.
Smith, Graham +2 more
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Journal of Chromatography A, 2000
Two polymers binding the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) were prepared by utilising the technique of the non-covalent molecular imprinting polymerisation in an aqueous medium. The polymers obtained were packed in HPLC columns and the effects of the mobile phase composition on the retention of the imprinting molecule and the ...
BAGGIANI, Claudio +4 more
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Two polymers binding the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) were prepared by utilising the technique of the non-covalent molecular imprinting polymerisation in an aqueous medium. The polymers obtained were packed in HPLC columns and the effects of the mobile phase composition on the retention of the imprinting molecule and the ...
BAGGIANI, Claudio +4 more
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
2,4,5-Trichlorophenoxyacetic acid and hexachlorophene are potent inhibitors of ribonucleotide reductase from developing brain. The inhibition was partially reversed by Fe2+. Administration of 2,4,5-trichlorophenoxyacetic acid to pregnant rats resulted in inhibition of fetal cerebral ribonucleotide reductase assayed in vitro.
S A, Millard, M B, Hart, J F, Shimek
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2,4,5-Trichlorophenoxyacetic acid and hexachlorophene are potent inhibitors of ribonucleotide reductase from developing brain. The inhibition was partially reversed by Fe2+. Administration of 2,4,5-trichlorophenoxyacetic acid to pregnant rats resulted in inhibition of fetal cerebral ribonucleotide reductase assayed in vitro.
S A, Millard, M B, Hart, J F, Shimek
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Journal of the Science of Food and Agriculture, 1964
AbstractThe extraction and determination by gas chromatography of 2,4‐dichloro‐ (2,4‐D) and 2,4,5‐trichloro‐phenoxyacetic acids (2,4,5‐T) as their methyl esters when present together in lawn fertilisers is described. The recovery of these herbicides varies with the composition of the fertiliser and four formulations have been studied to cover the most ...
J. K. Bradley, W. K. Thompson
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AbstractThe extraction and determination by gas chromatography of 2,4‐dichloro‐ (2,4‐D) and 2,4,5‐trichloro‐phenoxyacetic acids (2,4,5‐T) as their methyl esters when present together in lawn fertilisers is described. The recovery of these herbicides varies with the composition of the fertiliser and four formulations have been studied to cover the most ...
J. K. Bradley, W. K. Thompson
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