Results 21 to 30 of about 119,457 (222)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Cross product of vectors

, 2016
Vectors, cross product, dot productThis Demonstration computes and displays the cross product w = uXv (black) of two vectors u(red) and v(blue) in three dimensions. The dot product u.v of the vectors is a scalar (number), while the cross product uXv is a
Blinder, S. M., Blinder, Amy
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Almost paracontact structures obtained from G*2(2) structures

, 2018
In this paper, we construct almost paracontact metric structures by using the fundamental 3-forms of manifolds with G*(2(2))structures. The existence of certain almost paracontact metric structures is investigated due to the properties of the 2-fold ...
Solgun, Mehmet, Ozdemir, Nulifer, Aktay, Sirin   +2 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Sentiment analysis: text, pre-processing, reader views and cross domains [PDF]

, 2015
This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University LondonSentiment analysis has emerged as a field that has attracted a significant amount of attention since it has a wide variety of applications that ...
Haddi, Emma
core  

Dose-response tests and semi-field evaluation of lethal and sub-lethal effects of slow release pyriproxyfen granules (Sumilarv®0.5G) for the control of the malaria vectors Anopheles gambiae sensu lato. [PDF]

, 2013
BACKGROUND: Recently research has shown that larviciding can be an effective tool for integrated malaria vector control. Nevertheless, the uptake of this intervention has been hampered by the need to re-apply larvicides frequently.
Mbare, O., Mbare, Oscar, Lindsay, S.W., Lindsay, Steven W, Ulrike Fillinger, Fillinger, Ulrike, Oscar Mbare, Fillinger, U., Steven W Lindsay   +8 more
core   +1 more source

Multi-centre discriminating concentration determination of broflanilide and potential for cross-resistance to other public health insecticides in Anopheles vector populations [PDF]

, 2022
Novel insecticides are urgently needed to control insecticide-resistant populations of Anopheles malaria vectors. Broflanilide acts as a non-competitive antagonist of the gamma-aminobutyric acid receptor and has shown prolonged effectiveness as an indoor
Small, Graham, Mark Rowland, Kirby, Matthew J, Kirby, Matthew J., Tungu, Patrick K, Kristan, Mojca, George Mlay, Franklin W. Mosha, Njelembo J. Mbewe, Prisca Levy, Mbewe, Njelembo J., Portwood, Natalie M, Natalie M. Portwood, Shayo, Magreth F., Matthew J. Kirby, Graham Small, William Kisinza, Mlay, George, Mosha, Franklin W., Levy, Prisca, Louisa A. Messenger, Patrick K. Tungu, Thomas Walker, Rowland, Mark, Mojca Kristan, Messenger, Louisa A, Shayo, Magreth F, Mbewe, Njelembo J, Walker, Thomas, Magreth F. Shayo, Messenger, Louisa A., Janneke Snetselaar, Kisinza, William, Snetselaar, Janneke, Mosha, Franklin W, Portwood, Natalie M., Tungu, Patrick K.   +36 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source