Results 31 to 40 of about 139,462,453 (100)

Improving upon Nature: Active Site Remodeling Produces Highly Efficient Aldolase Activity toward Hydrophobic Electrophilic Substrates

open access: yes, 2016
The substrate specificity of enzymes is frequently narrow and constrained by multiple interactions, limiting the use of natural enzymes in biocatalytic applications.
Eric J. Toone (523230)   +2 more
core   +1 more source

The non-phosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate specific aldolase (KDGA)

open access: yes, 2010
The pathway of glucose degradation in the thermoacidophilic euryarchaeon Picrophilus torridus has been studied by in vivo labeling experiments and enzyme analyses. After growth of P.
Fuhrer, T.   +3 more
core   +1 more source

Crystal structure and stereochemical studies of KD(P)G aldolase from Thermoproteus tenax

open access: yes, 2008
Carbon–carbon bond forming enzymes offer great potential for organic biosynthesis. Hence there is an ongoing effort to improve their biocatalytic properties, regarding availability, activity, stability, and substrate specificity and selectivity ...
Pauluhn, Anuschka (author)   +13 more
core   +1 more source

Gene abundance and expression for key indicator enzymes associated with glycolysis.

open access: yes, 2015
Abundance (a) and expression (b) of the key enzyme in the Embden-Meyerhof (EMP) pathway, 6-phosphofructokinase, represented by COG205. Abundance (c) and expression (d) of the key enzyme in the pathway Entner-Doudoroff (ED) pathway, 2-keto-3-deoxy-6 ...
Byron C. Crump (239884)   +1 more
core   +1 more source

Story about honest mistakes: The cyanobacterium Synechocystis has a promiscuous Entner-Doudoroff (ED) aldolase but no functional ED pathway

open access: yes
In 2016, the glycolytic Entner-Doudoroff (ED) pathway was reported in cyanobacteria and plants (1). The claim was based on the biochemical characterization of its key enzyme the 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase also named ED aldolase ...
Martin Hagemann   +10 more
core   +1 more source

6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species

open access: yes, 1998
The mechanism of action of 6-phosphogluconate dehydrogenase with the alternative substrate 2-deoxy 6-phosphogluconate was investigated using enzymes from sheep liver, human erythrocytes and Trypanosoma brucei.
GIOVANNINI, Pier Paolo   +9 more
core   +1 more source

The central metabolism of Mtm. alcaliphilum 20Z.

open access: yes, 2019
1 –pyruvate kinase (accession number CCE24746), 2 –pyrophosphate type of phosphoenolpyruvate carboxykinase (WP_014148666), 3 –malate dehydrogenase (CCE24885), 4 –malic enzyme (CCE22813), 5 –pyruvate, phosphate dikinase (CCE23390), 6 –phosphoenolpyruvate ...
Sergei Y. But (7878656)   +4 more
core   +1 more source

NADPH activates a decarboxylation reaction catalysed by lamb liver 6-phosphogluconate dehydrogenase

open access: yes, 1992
NADP-dependent lamb liver 6-phophogluconate dehydrogenase catalyses the oxidative decarboxylation of 2-deoxy-6-phosphogluconate, an analogue of the natural substrate. The first products of the reaction are NADPH and 3-keto-2-deoxy-6-phosphogluconate. The
HANAU, Stefania   +2 more
core   +1 more source

The chemical synthesis of 2-keto-3-deoxy-octonate and its cleavage by a specific aldolase

open access: yes, 1963
We have previously reported (Heath and Ghalambor, 1963) the occurrence of 2-keto-3-deoxy-octonate (KDO) as a glycosidically-bound constituent of cell wall lipopolysaccharide (LPS) of 0111-B4 and the enzymatic synthesis of CMP-KDO (Ghalambor and Heath ...
Heath, Edward C.   +1 more
core   +1 more source

INITIAL FUNCTIONAL CHARACTERIZATION OF BFO 2291 AND BFO 2294 FROM Tannerella forsythia; DEGRADERS OF CHONDROITIN SULFATE A [PDF]

open access: yes, 2018
Periodontitis is characterized by the inflammation of the periodontal tissues in response to bacterial action. The Global Burden of Disease (GBD) 2010 study shows that periodontitis ranks 6thin the global prevalence of oral health conditions and affects ...
Eshaque, Rony
core  

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