Results 71 to 80 of about 9,033 (258)

Variant‐Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs

International Journal of Cancer, EarlyView.
Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens, Jan‐Patrick Hetzel, Khaldoon Abdullah, Carolien Eggermont, Catharina Olsen, Marco Mernberger, Ken Maes, Jelle Vlaeminck, Rainer Claus, Dries Vanisterbecq, Frederik Hes, Martin Pichler, Philippe Giron, Oleg Timofeev, Maxim Noeparast   +14 more
wiley   +1 more source

A multiple attribute group decision making model based on 2-tuple linguistic pythagorean fuzzy dombi aggregation operators for optimal selection of potential global suppliers

Heliyon
Multiple-Attribute Group Decision-Making (MAGDM) is a significant area of research in decision-making, and its principles and methodologies are widely implemented. A Pythagorean Fuzzy Set (PFS) is an extension of an Intuitionistic Fuzzy Set (IFS) that is
Tmader Alballa, Ahmed Alamer, Khadija Nasir, Awais Yousaf, Somayah Abdualziz Alhabeeb, Hamiden Abd El-Wahed Khalifa   +5 more
doaj   +1 more source

Towards an Extension of the 2-tuple Linguistic Model to Deal With Unbalanced Linguistic Term sets

Kybernetika, 2013
In the domain of Computing with words (CW), fuzzy linguistic approaches are known to be relevant in many decision-making problems. Indeed, they allow us to model the human reasoning in replacing words, assessments, preferences, choices, wishes... by ad hoc variables, such as fuzzy sets or more sophisticated variables. This paper focuses on a particular
Abchir, Mohammed-Amine, Truck, Isis
openaire   +5 more sources

Researcher–Entrepreneur Relationship and Performance of Innovative Startups

International Journal of Finance &Economics, EarlyView.
ABSTRACT Many innovative startups are joint ventures between researchers and entrepreneurs, who collaborate in R&D and product commercialization. Government policies such as grants, subsidies, and patent licensing fees act as Pigouvian subsidies, incentivizing R&D by bridging the gap between the social and private returns of innovation.
Yangguang Huang, Helen Hui
wiley   +1 more source

On the Hardness of Switching to a Small Number of Edges

Journal of Graph Theory, EarlyView.
ABSTRACT Seidel's switching is a graph operation which makes a given vertex adjacent to precisely those vertices to which it was non‐adjacent before, while keeping the rest of the graph unchanged. Two graphs are called switching‐equivalent if one can be made isomorphic to the other one by a sequence of switches. Jelínková et al. [DMTCS 13, no. 2, 2011]
Vít Jelínek, Eva Jelínková, Jan Kratochvíl   +2 more
wiley   +1 more source

Exact Solutions of Linear Multiple Delay Partial Differential Equations

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT This paper develops an analytical framework for linear differential equations with multiple discrete delays. A new function, referred to as the multiple‐delay exponential function, is introduced, and some of its fundamental properties are established.
Stuart‐James M. Burney
wiley   +1 more source

Multi‐Agent Reinforcement Learning for Joint Police Patrol and Dispatch

Naval Research Logistics (NRL), EarlyView.
ABSTRACT Police patrol units need to split their time between performing preventive patrol and being dispatched to serve emergency incidents. In the existing literature, patrol and dispatch decisions are often studied separately. We consider joint optimization of these two decisions to improve police operations efficiency and reduce response time to ...
Matthew Repasky, He Wang, Yao Xie
wiley   +1 more source

Improving Affordability and Accessibility for Socially‐Beneficial Services via Government Incentives

Naval Research Logistics (NRL), EarlyView.
ABSTRACT Many socially‐beneficial services, like dental care, suffer from a dual challenge: Low affordability for citizens and long waiting times due to insufficient provider capacity. We model a government's problem of designing subsidy policies to address this issue.
Xiaoyan Zhao, Venus Lo, Stephen Shum
wiley   +1 more source

Allocation of Indivisible Items With a Common Preference Graph: Minimizing Total Dissatisfaction

Networks, EarlyView.
ABSTRACT Allocating indivisible items among a set of agents is a frequently studied discrete optimization problem. In the setting considered in this work, the agents' preferences over the items are assumed to be identical. We consider a very recent measure for the overall quality of an allocation which does not rely on numerical valuations of the items.
Nina Chiarelli, Clément Dallard, Andreas Darmann, Stefan Lendl, Martin Milanič, Peter Muršič, Ulrich Pferschy   +6 more
wiley   +1 more source

Optimal Homogeneous ℒp$$ {\boldsymbol{\mathcal{L}}}_{\boldsymbol{p}} $$‐Gain Controller

International Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT Nonlinear ℋ∞$$ {\mathscr{H}}_{\infty } $$‐controllers are designed for arbitrarily weighted, continuous homogeneous systems with a focus on systems affine in the control input. Based on the homogeneous ℒp$$ {\mathcal{L}}_p $$‐norm, the input–output behavior is quantified in terms of the homogeneous ℒp$$ {\mathcal{L}}_p $$‐gain as a ...
Daipeng Zhang, Benjamin Calmbach, Jaime A. Moreno, Johann Reger   +3 more
wiley   +1 more source