Results 91 to 100 of about 25,547,481 (294)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Verdades sobre los 200 días

open access: yesEnsayos Pedagógicos, 2004
El debate sobre la duración del curso lectivo en las escuelas y colegios públicos, se ha empantanado. Ahora resulta que la gran cuestión a decidir es si el curso dura 200 o 174 días. ¡Cómo si esos fueran números mágicos!
Sonia Roblero Rodríguez
doaj  

200 Countries and 200 Years in 4 Minutes

open access: yes, 2010
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openaire   +1 more source

Bottleneck

open access: yes, 1991
Published to accompany the exhibition held at 200 Gertrude Street, 1-23 November ...
200 Gertrude Street (Gallery)
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Darren Sylvester : life together.

open access: yes, 1998
Catalogue of an exhibition held at 200 Gertrude Street, Fitzroy, Vic., 6-28 Mar ...
200 Gertrude Street (Gallery)
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Profiling cells with DELs: Small molecule fingerprinting of cell surfaces

open access: yesSLAS Discovery
DNA-encoded small molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, it has been used to identify ligands against targets that are soluble or overexpressed on cell surfaces.
Jason Deng   +14 more
doaj   +1 more source

David Hecht.

open access: yes, 1990
Catalogue for exhibition held Friday 2 March - Saturday 31 March, 1990 at 200 Gertrude ...
200 Gertrude Street (Gallery)
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

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