Results 91 to 100 of about 6,302,624 (294)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

1975 1985

, 1987
Catalogue of an exhibition held at 200 Gertrude Street, Fitzroy, 20 November - 12 December 1987.Curator: Lesley ...
200 Gertrude Street (Gallery)
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200 Countries and 200 Years in 4 Minutes

, 2010
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openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

I knelt beside a stream

, 1996
Catalogue of an exhibition held at 200 Gertrude Street, Fitzroy, Vic., 6-28 Sept. 1996.
200 Gertrude Street (Gallery)
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Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Peripheral visions : Andrew Arnaoutopoulos, Graeme Hare, Constanze Zikos

, 1992
Catalogue of an exhibition held at 200 Gertrude Street, Fitzroy, Vic. 2-31 Oct.
200 Gertrude Street (Gallery)
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Profiling cells with DELs: Small molecule fingerprinting of cell surfaces

SLAS Discovery
DNA-encoded small molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, it has been used to identify ligands against targets that are soluble or overexpressed on cell surfaces.
Jason Deng, Svetlana Belyanskaya, Ninad Prabhu, Christopher Arico-Muendel, Hongfeng Deng, Christopher B. Phelps, David I. Israel, Hongfang Yang, Joseph Boyer, G. Joseph Franklin, Jeremy L. Yap, Kenneth E. Lind, Ching-Hsuan Tsai, Christine Donahue, Jennifer D. Summerfield   +14 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Raafat Ishak and government and sport and book and key and money and paint and cat and bed and water and food and blanket and hop and paper and drum

, 1995
Catalogue of an exhibition held at 200 Gertrude Street, Fitzroy, Vic. 7 - 29 Apr.
200 Gertrude Street (Gallery)
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