Results 131 to 140 of about 3,811,869 (264)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Multimodal evaluation of 525 nm laser-induced retinal injury in rabbits: structural, functional and cytokine analyses. [PDF]

Lasers Med Sci
Guo L, Chen K, Li G, Zeng J, Fan Z, Li C, Zou Y, Xu J, Zhang J.   +8 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

<i>In-vivo</i> antidiarrheal activity of aqueous and hydroethanolic extracts of <i>Anacardium occidentale</i> and <i>Khaya senegalensis</i> used in Benin (West Africa) in a castor oil-induced diarrhea model traditionally. [PDF]

Front Pharmacol
Hounsa E, Fagla SM, Agbodjento E, Klotoe JR, Dougnon VT.   +4 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Drug Interactions of Vebreltinib, a Novel Type I c-Met Inhibitor, Coadministration With Rifampin or Itraconazole in Healthy Participants. [PDF]

Clin Transl Sci
Chen J, Wu J, Song Y, Li J, Li L, Li L, Kong Y, Wu X, Yin H, Hou M, Wang B, Gao Q, Li R, Wu L, Xue W, Dong R.   +15 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Effect of pulsed ultrasound pretreatment on enzymatic hydrolysis and bio-functional properties of luffa cylindrica seed protein hydrolysates. [PDF]

Ultrason Sonochem
Tabarestani HS, Samie MM, Mahoonak AS, Moayedi A.   +3 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Antagonizing NRG1-ERBB4 signaling pathway with spironolactone for the treatment of schizophrenia: results of a randomized controlled drug repositioning clinical trial. [PDF]

Commun Med (Lond)
Hasan A, Leucht S, Roeh A, Langguth B, Hansbauer M, Oviedo-Salcedo T, Greiner SK, Papazova I, Löhrs L, Maurus I, Strube W, Rossner MJ, Wehr MC, Bauer I, Heres S, Kreuzer PM, Zimmermann S, Schneider-Axmann T, Görlitz T, Baumgartner A, Karch S, Egert-Schwender S, Blankenstein C, Rothe P, Wagner E, Aminifarsani Z, Downie B, Leucht C, Falkai P.   +28 more
europepmc   +1 more source